Sexual functions and fertility outcomes after hypospadias repair

Gül, Murat; Hildorf, Simone; Silay, Mesrur Selçuk

doi:10.1038/s41443-020-00377-5

Cited by 18 publications

(8 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can be corrected at any age, without signi cant difference in the risk of complications, functional recovery and cosmetic effect. However, correction at an earlier stage is recommended by most researchers [3]. At present, there are many corrective operations for hypospadias, yet accompanied by relatively higher incidence of postoperative complications.…”

Section: Introductionmentioning

confidence: 99%

Clinical Value of Microsurgery Combined with Covering New Urethra by Multilayer Sarcolemma Tissues in the Treatment of Hypospadias in Male Children and Analysis of Urodynamic Parameters

Zheng,

Guo,

Shi

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective To compare and analyze differences in the clinical effect and postoperative urodynamic indexes of microsurgery combined with covering new urethra by multilayer sarcolemma tissues and conventional surgery alone in the treatment of male children with hypospadias. Methods A total of 80 male children with penile hypospadias who were hospitalized in Beijing Children's Hospital Affiliated to Capital Medical University Baoding Hospital were randomly divided into two groups, with 40 in each group. Children in the study group underwent microsurgery combined with covering new urethra by multilayer sarcolemma tissues, while those in the control group were provided with traditional tubularized incised plate (TIP) urethroplasty alone. Further comparative analysis was performed on the operation effect, operation time, total intraoperative bleeding, postoperative length of stay in the hospital and the incidence of surgical complications between the two groups. All male children were followed up for 6 months to compare and analyze the changes of urodynamic parameters such as maximum urinary flow rate (Qmax), mean urinary flow rate (Qavc), post-void residual urine (PVR) before and after surgery. Results There were statistically significant differences that the operation time(p = 0.03) was longer while the postoperative length of stay in the hospital (p = 0.000) was shorter in the study group than those in the control group. The effective rate of the study group was 97.50%, while that of the control group was 82.50%, with statistically significant difference (p = 0.025). The incidence of surgical complications was 7.50% in the study group and 25.00% in the control group 3 months after operation (p = 0.034). There was statistically significant difference that the Hose score of the study group was significantly higher than that of the control group (p = 0.000). Meanwhile, there was no significant difference in indicators such as Qmax, Qavc and PVR between the two groups before surgery; while the levels of Qmax and Qavc in the study group were higher than those in the control group 6 months after surgery, with statistically significant difference (p = 0.000). Conclusion Microsurgery combined with covering new urethra by multilayer sarcolemma tissues has certain clinical value in the treatment of male children with hypospadias, which shows good therapeutic effect, shorter length of stay in the hospital, lower incidence of postoperative complications, and significantly improved urodynamic indicators, despite slightly complicated operation and relatively longer duration of operation.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical Value of Microsurgery Combined with Covering New Urethra by Multilayer Sarcolemma Tissues in the Treatment of Hypospadias in Male Children and Analysis of Urodynamic Parameters

Zheng,

Guo,

Shi

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…However, the etiology of most patients with hypospadias remains unclear. Hypospadias is thought to be a clinical manifestation of the interaction of hormonal and genetic factors during the development of the external genitalia [2]. Recent epigenetic investigations have identified an imbalance in human foreskin fibroblasts (HFF) as an important aspect of the disease etiology [3].…”

Section: Introductionmentioning

confidence: 99%

Testosterone promotes human foreskin fibroblast growth through miR-143-3p targeting IGFBP-3

2023

Journal of Men's Health

View full text Add to dashboard Cite

Testosterone is an important male hormone, which could improve the maintenance and recovery of gonadal function in males as well as the repair of human hypospadias and cell fibrosis. Our study focused on investigating the regulatory effect of testosterone in human foreskin fibroblasts (HFF-1) and regulatory mechanisms involved. In this study, HFF-1 cells were treated with testosterone, and cell viability and migration were assessed by cell counting kit-8 (CCK8) and Transwell assays. The expression levels of androgen receptor (AR), miR-143-3p and insulin-like growth factor binding protein-3 (IGFBP-3) were measured by quantitative real-time PCR (qRT-PCR), Western blotting, and immunofluorescence. In addition, a potential binding site for miR-143-3p on IGFBP-3 was predicted and its direct binding was further confirmed by a dual luciferase reporter assay. These results showed that testosterone increased the viability and migration of HFF-1 cells. Testosterone could down-regulate miR-143-3p and up-regulate IGFBP-3 and AR. Overexpression of miR-143-3p hindered HFF-1 cell viability and negatively regulated IGFBP-3, whereas inhibition of IGFBP-3 impeded cell viability and migration. Furthermore, miR-143-3p was found to directly bind to IGFBP-3. Overexpression of IGFBP-3 countered the regulation of HFF-1 cells by miR-143-3p mimics. In conclusion, this study showed that testosterone promoted the proliferation and migration of HFF-1 cells and AR signaling, at least via the miR-143-3p/IGFBP-3 axis. This discovery presents a novel insight for testosterone application in male disorders like hypospadias.

show abstract

“…Most children develop gender consciousness from around 18 months, then gradually establish urination habits. Children’s memory of early surgery is conducive to their mental health development after adolescence, and early surgery can avoid challenges caused by urination problems and improve their quality of life and social adaptability [ 6 , 7 ]. In 2021, the European Association of Urology (EAU) Guidelines on Pediatric Urology recommended that children undergoing hypospadias surgery should be between 6 and 18 months [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics, socioeconomic factors and COVID-19 were associated with delayed surgery in children with hypospadias: a retrospective study of 4439 cases in a single center

et al. 2022

View full text Add to dashboard Cite

Background Hypospadias is one of the most common congenital diseases of the genitourinary system in children. The European Association of Urology (EAU) Guidelines recommend that children undergoing hypospadias surgery should be between 6 and 18 months. In China, where many children have hypospadias, it remains unknown whether clinical characteristics, socioeconomic factors and COVID-19 were associated with delayed surgery in children with hypospadias. Methods We retrospectively analyzed children with hypospadias who underwent primary surgery at the Department of Pediatric Urology in Guangzhou Women and Children’s Medical Center between January 2010 and October 2021. Patients who had two-stage surgery or a second round of surgery due to complications were excluded to eliminate data duplication. The clinical characteristics and demographic information were collected. We defined delayed surgery as primary surgery performed after 18 months following the EAU Guidelines. Results A total of 4439 children diagnosed with hypospadias were included in the study. The median age (29.1 ± 16.7 months) of surgery for hypospadias in our study was much higher than the recommended age reported in the EAU guidelines, and 76.6% of the children underwent surgery after the age of 18 months. Children without comorbidities including cryptorchidism (odds ratio [OR] = 1.562; 95% confidence interval [CI] 1.199–2.034; p = 0.001), prostatic cyst (OR = 2.613; 95% CI 1.579–4.324; p < 0.001), penile hypoplasia (OR = 1.778; 95% CI 1.225–2.580; p = 0.002), inguinal hernia (OR = 2.070; 95% CI 1.394–3.075; p < 0.001), and penoscrotal transposition (OR = 4.125; 95% CI 1.250–13.619; p = 0.020) were more likely to receive delayed surgery. Living in a low economic area (OR = 1.731; 95% CI 1.068–2.806; p = 0.026) or not close to a main medical center (OR = 1.580; 95% CI 1.370–1.824; p < 0.001) was highly associated with delayed surgery. The proportion of children undergoing delayed surgery and the median age of surgery during the COVID-19 pandemic were significantly higher than those before the COVID-19 pandemic (p = 0.004 and < 0.001, respectively). Conclusions Most children with hypospadias received delayed surgery (surgical age > 18 months). Comorbidities, living in a low economic area, too far from a main medical center and the COVID-19 pandemic were highly associated with delayed surgery. It is vital to improve the public awareness of hypospadias and strengthen the re-education of primary community doctors to reduce delayed surgery.

show abstract

Sexual functions and fertility outcomes after hypospadias repair

Cited by 18 publications

References 60 publications

Clinical Value of Microsurgery Combined with Covering New Urethra by Multilayer Sarcolemma Tissues in the Treatment of Hypospadias in Male Children and Analysis of Urodynamic Parameters

Clinical Value of Microsurgery Combined with Covering New Urethra by Multilayer Sarcolemma Tissues in the Treatment of Hypospadias in Male Children and Analysis of Urodynamic Parameters

Testosterone promotes human foreskin fibroblast growth through miR-143-3p targeting IGFBP-3

Clinical characteristics, socioeconomic factors and COVID-19 were associated with delayed surgery in children with hypospadias: a retrospective study of 4439 cases in a single center

Contact Info

Product

Resources

About