Sexual hormone abnormalities in male patients with renal failure

Schmidt, Alice; Luger, Anton; Hörl, Walter H.

doi:10.1093/ndt/17.3.368

Cited by 67 publications

(60 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increased levels of serum prolactin and altered signaling of luteinizing hormone by uremia is considered Effect of ADMA levels in ED to play a role in testosterone deficiency. 26,27 Yılmaz et al reported lower levels of testosterone in patients with CKD, even at early stages of the disease. 28 In our group of patients with CKD, the serum levels of testosterone were significantly lower than the control group.…”

Section: Discussionmentioning

confidence: 99%

“…The degree of ED was divided into five categories: no ED (scores of [26][27][28][29][30], mild (scores of [22][23][24][25], mild-to-moderate (scores of 17-21), moderate (scores of [11][12][13][14][15][16], and severe (scores of 6-10). 12 Groups were composed as follows: group1: patients with CKD and ED; group 2: patients with CKD without ED; group 3: control patients without CKD or ED.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of ADMA levels on severity of erectile dysfunction in chronic kidney disease and other risk factors

Gökçen

Kılıçarslan

Çoşkun

et al. 2016

CUAJ

View full text Add to dashboard Cite

Introduction: Hormonal, neurogenic, vasculogenic, and psychogenic impairments, as well as endothelial dysfunction may play a role in erectile dysfunction (ED) in patients with chronic kidney disease (CKD). Asymmetrical dimethylarginine (ADMA) is an inhibitor of nitric oxide, which is the key element of ED. ADMA levels are increased in CKD. We aimed to evaluate the effect of serum ADMA, prolactin, testosterone, and hemoglobin levels on erectile function of patients with CKD and control subjects. Methods: A total of 42 men with CKD and 25 age-matched controls were enrolled. The patients with CKD were categorized into group 1 and group 2 based on whether they had ED according to their response to International Index of Erectile Function questionnaire (IIEF-EFD). Group 3 was a control group. Serum ADMA, total testosterone prolactin, and hemoglobin levels of the patients were evaluated. Results: Serum ADMA, testosterone, and hemoglobin levels were similar between group 1 and 2, serum prolactin level was significantly high in group 1 than in group 2 or 3 (control group). There was no correlation between ADMA levels and IIEF-EFD scores of patients with CKD. Conclusions:The results of this study suggest serum ADMA level is not related with ED in patients with CKD. Also, low testosterone and hemoglobin levels were not significant factors. High levels of serum prolactin are related with ED in patients with CKD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effect of ADMA levels on severity of erectile dysfunction in chronic kidney disease and other risk factors

Gökçen

Kılıçarslan

Çoşkun

et al. 2016

CUAJ

View full text Add to dashboard Cite

show abstract

“…Also Schmidt et al [27] stated that impairment of hypothalamopitutary-gonadal axis is not reversed by initiation of otherwise effective hemodialysis or peritoneal dialysis therapy .…”

Section: Archives Of Medicine Issn 1989-5216mentioning

confidence: 99%

Study of Male Sex Hormone Levels in Male Egyptian Children and Adolescents with End Stage Renal Disease under Regular Haemodialysis

Gamasy¹,

Hasan²,

Amin³

et al. 2017

Arch Med.

View full text Add to dashboard Cite

IntroductionIn ESRD, gonadal hormones undergo several pathological changes which result in retardation of pubertal development [1]. These hormonal disturbances result in failure to thrive and delay the pubertal development [2]. About one third of male adolescents with CRF has a delayed puberty. Many pathophysiological mechanisms can explain pubertal delay in these patients [1] including hormonal disturbance in the hypothalamohypophyseal gonadal axis, toxic effects of uremia on peripheral tissues, testicular injury and disordered secretion and function of follicular stimulating hormone (FSH) and luteizing hormone (LH) which is known also as interstitial cell stimulating hormone (ICSH) secretion [3]. Study of Male Sex Hormone Levels in Male Egyptian Children and Adolescents with End Stage Renal Disease under Regular HaemodialysisAbstract Background: Delayed puberty is a common pathological finding in male children with chronic renal failure (CRF) secondary the pathological changes in testosterone hormone.

show abstract

“…Some metabolic alterations, including disorders in the secretion of hormones and the response of target tissues, causing several endocrine dysfunctions that contribute to worse outcomes [32] and [33]. Among those, hypogonadism (testosterone deficiency) is the most common gonadal alteration in men, mainly because of reduced prolactin clearance [34] and uremic inhibition of luteinizing hormone signaling at the level of the Leydig cells [35].…”

Section: Kidneymentioning

confidence: 99%

Effect of Testosterone on Lead Acetate Toxicity in Male Albino Rats

Mahmood

Hamad

Hassan

et al. 2017

KJAR

View full text Add to dashboard Cite

Abstract:The toxicity of lead acetate (L. A.) concerned to public health disruptor due to its persistence in the environment and it has the adverse influence on the human and animal health as well. It causes physiological,biochemical, and neurological dysfunctions in humans. Histologically it has a negative effect on the liver which is considered one of the major target organs where acts as detoxification machine by elimination the toxic substance from the blood in rich with it. As well as it affects kidneys that are the two of the most filtering organs. Therefore the present study was aimed to investigate the histopathological effect of L.A. on liver and kidney tissues in male rats. Twenty male rats involved in the study were equally and randomly divided into two groups each of them involved 10 animals. Group I (castrated rats) and Group II (control) each group received 80mg/L of lead acetate dissolved in one liter distilled water by drinking for 15 days. Histological sections showed some alterations including abnormal architecture, cell degeneration, nuclear degeneration, hyperchromatic hepatocytes, immune cells, degeneration in tubules, dilation in sinusoids, dilation in central vein of liver increased bowman's space glomerular atrophy degeneration of tubular cells in liver and kidney tissues of rats in castrated rats from control group. But the size of degenerated tissue was more severe in castrated male rats. It was concluded that the castration process could produce a hypogonadism and decreased testosterone which owns many receptors in kidney and liver may produce adverse influence with L.A. administration.

show abstract

Sexual hormone abnormalities in male patients with renal failure

Cited by 67 publications

References 24 publications

Effect of ADMA levels on severity of erectile dysfunction in chronic kidney disease and other risk factors

Effect of ADMA levels on severity of erectile dysfunction in chronic kidney disease and other risk factors

Study of Male Sex Hormone Levels in Male Egyptian Children and Adolescents with End Stage Renal Disease under Regular Haemodialysis

Effect of Testosterone on Lead Acetate Toxicity in Male Albino Rats

Contact Info

Product

Resources

About