Sexual hormone serum levels and temporomandibular disorders. A preliminary study

Landi, Nicola; Lombardi, I; Manfredini, Daniele; Casarosa, Elena; Biondi, Katya; Gabbanini, Massimo; Bosco, Mario

doi:10.1080/09513590400021136

Cited by 52 publications

(50 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The preponderance of women in the present study is consistent with previous findings (6). Attempts to explain female dominance among TMJD patients have identified several potential predisposing factors, including the effects of gonadal hormones such as estrogen, progesterone, and relaxin (17,18). These hormones are believed to have a degenerative effect on the disc and/or bone of the mandibular condyle.…”

Section: Discussionsupporting

confidence: 82%

Are there early signs that predict development of temporomandibular joint disease?

Fredricson

Khodabandehlou

Weiner

et al. 2018

Journal of Oral Science

View full text Add to dashboard Cite

Temporomandibular joint disorders(TMJD) involve orofacial pain and functional limitations that may limit important daily activities such as chewing and speaking. This observational casecontrol study attempted to identify factors associated with TMJD development, particularly inflammation. The study participants were patients treated at Karolinska University Hospital, Stockholm, Sweden. The cases were patients who received a diagnosis of TMJD, chronic closed lock, or painful clicking and were treated surgically during the period from 2007 through 2011. The control group was randomly selected from among patients who had undergone tooth extraction and was matched by age and sex. A total of 146 cases and 151 controls were included in the analyses. The response rate was 55.3% for the case group and 21.8% for the control group. The male:female ratio for patients with TMJD was 1:4.4. TMJD was significantly associated with pneumonia (odds ratio [OR], 2

show abstract

Section: Discussionsupporting

confidence: 82%

Are there early signs that predict development of temporomandibular joint disease?

Fredricson

Khodabandehlou

Weiner

et al. 2018

Journal of Oral Science

View full text Add to dashboard Cite

show abstract

“…The mechanisms underlying these sex-related differences remain obscure and likely involve both psychologic and physiologic factors [4]. The role of the sexual hormones (estrogens) which appear to alter the excitability of trigeminal afferent fibers to noxious stimulation of craniofacial tissues, is supported by several human [35][36][37] and animal [13] studies. However, the effect of estrogens in the etiology of TMD seems complex and could depend upon various conditions, for example the acute (antiinflammatory effect) or chronic (tissular destruction) nature of the pain [7].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of risk factors for temporomandibular disorders: a retrospective survey from 300 consecutive patients seeking care for TMD in a French dental school

Robin

Chiomento

2010

J. Stomat. Occ. Med.

View full text Add to dashboard Cite

Purpose: The purpose of this study was to observe the prevalence of the different diagnostic groups of TMD disorders (articular, muscular, and associated disorders) and the prevalence of the different TMD risk factors from a population of patients seeking specialized care in the TMD clinic at a public dental school.Materials and methods: Data were collected from the retrospective analysis of archival records of 500 consecutive new patients who attended the TMD clinic at the Dental School of Lyon, France, over a 4-year period. The diagnostic criteria were based on those defined by the American Academy of Orofacial Pain: articular disorders (TMJ pain, disc displacement with or without reduction, osteoarthritis and osteoarthrosis), masticatory and cervical muscle disorders, and associated symptoms (migraine/tension-type headache, tinnitus, dizziness). The diagnosis was mainly made based on clinical history and clinical examination of the patient performed by the same trained examiner. In addition, an oral questionnaire was submitted to each patient in order to list all potential risk factors for TMD which were classified into five groups: traumatic, oral parafunctions, psychologic, occlusal, and systemic.Results: The selected population was composed of 300 patients including 232 females (77.3%) and 68 males (22.7%) corresponding to a female-to-male ratio of 3.4:1. Disc displacement with reduction (66.7% of the patients) and muscular tenderness/masseter hypertrophy (62.3%) were the two most prevalent TMD symptoms followed by masticatory myofacial pain (38%) and TMJ pain (29.6%). Associated disorders represented almost 9% of the symptoms, headache being the most prevalent one (14.3% of the patients). Oral parafunctions represented the most important risk factor group (n ¼ 489, 36.9%) followed by traumatic factors (n ¼ 354, 26.7%) and psychologic factors (n ¼ 257, 19.4%). The weakest percentage was obtained for the occlusal factors (n ¼ 57, 4.3%). When all risk factors are considered individually, the two most prevalent factors identified on this population were tooth clenching (77% of the patients) and self-reported stress (59.3%) followed by antecedents of extraction of wisdom teeth (34.3%), endotracheal intubation (30.7%), biting habits (29.3%), gum chewing (28%), and previous orthodontic treatment (28%).Conclusion: The results of this study emphasized the high prevalence of disc displacement with reduction and muscular tenderness to palpation among the TMD diagnostic groups and the high prevalence of tooth clenching and psychologic factors (stress) among the risk factors. It may be hypothesized that stress affects TMD symptoms by increasing clenching habits thus predisposing to disc displacement. This is supported by the results of a recent study which showed that daytime tooth clenching/grinding is a significant risk factor for myofacial pain and disc displacement (Michelotti et al., 2010). The prevention of tooth clenching appears to be an essential component of the treatment of temporomandibular disorders.

show abstract

“…Similar to RA, TMDs are approximately twice as prevalent (and more severe) in women than in men (6,7). Sex hormones, particularly estrogens, are reported to be involved in TMD (6,(8)(9)(10). We also previously reported that estrogen aggravates TMJ inflammation through the induction of proinflammatory cytokines in the synovial membrane (11).…”

mentioning

confidence: 90%

Estradiol Promotes M1-like Macrophage Activation through Cadherin-11 To Aggravate Temporomandibular Joint Inflammation in Rats

Kou¹,

et al. 2015

The Journal of Immunology

View full text Add to dashboard Cite

Macrophages play a major role in joint inflammation. Estrogen is involved in rheumatoid arthritis and temporomandibular disorders. However, the underlying mechanism is still unclear. This study was done to verify and test how estrogen affects M1/M2-like macrophage polarization and then contributes to joint inflammation. Female rats were ovariectomized and treated with increasing doses of 17β-estradiol for 10 d and then intra-articularly injected with CFA to induce temporomandibular joint (TMJ) inflammation. The polarization of macrophages and expression of cadherin-11 was evaluated at 24 h after the induction of TMJ inflammation and after blocking cadherin-11 or estrogen receptors. NR8383 macrophages were treated with estradiol and TNF-α, with or without blocking cadherin-11 or estrogen receptors, to evaluate the expression of the M1/M2-like macrophage-associated genes. We found that estradiol increased the infiltration of macrophages with a proinflammatory M1-like predominant profile in the synovium of inflamed TMJ. In addition, estradiol dose-dependently upregulated the expressions of the M1-associated proinflammatory factor inducible NO synthase (iNOS) but repressed the expressions of the M2-associated genes IL-10 and arginase in NR8383 macrophages. Furthermore, estradiol mainly promoted cadherin-11 expression in M1-like macrophages of inflamed TMJ. By contrast, blockage of cadherin-11 concurrently reversed estradiol-potentiated M1-like macrophage activation and TMJ inflammation, as well as reversed TNF-α–induced induction of inducible NO synthase and NO in NR8383 macrophages. The blocking of estrogen receptors reversed estradiol-potentiated M1-like macrophage activation and cadherin-11 expression. These results suggested that estradiol could promote M1-like macrophage activation through cadherin-11 to aggravate the acute inflammation of TMJs.

show abstract

Sexual hormone serum levels and temporomandibular disorders. A preliminary study

Cited by 52 publications

References 12 publications

Are there early signs that predict development of temporomandibular joint disease?

Are there early signs that predict development of temporomandibular joint disease?

Prevalence of risk factors for temporomandibular disorders: a retrospective survey from 300 consecutive patients seeking care for TMD in a French dental school

Estradiol Promotes M1-like Macrophage Activation through Cadherin-11 To Aggravate Temporomandibular Joint Inflammation in Rats

Contact Info

Product

Resources

About