Sexual Maturation and Psychiatric Morbidity among Persons with Sickle Cell Anaemia in a Nigerian Teaching Hospital

Aina, Olatunji F.; Fadaka, Kate; Temiye, Edamisan; Renner, James K.

doi:10.2190/pm.40.1.c

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…Although most of its use was among primary care and general population subjects, it has also been found useful also in screening other special groups for psychiatric morbidity. 31,32 The GHQ-12 has been found to be a reliable screening tool in this environment. 32,33,34 Scores of 2 and above on the GHQ 12 were suggestive of psychiatric morbidity.…”

Section: Burden Of Care (Boc) Schedulementioning

confidence: 99%

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Burden and psychological effects : caregiver experiences in a psychiatric outpatient unit in Lagos, Nigeria

Oshodi¹,

Adeyemi²,

Aina³

et al. 2012

Afr. J. Psych

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Objective: Worldwide, research into experiences of care givers are gradually increasing and their central role in community care is being acknowledged. Caregivers experience a multidimensional range of problems, often associated with their caregiving role. It becomes important to identify these areas of burden and provide necessary support. The study sought to determine the prevalence of psychological distress and experience of burden of care among the caregivers of mentally ill patients. Method: A cross sectional descriptive study. Eligible consecutive subjects were recruited to the study over a 6 month period. Fifty three caregiver relatives of patients diagnosed with a psychiatric illness were assessed using the General Health questionnaire version 12, an Adapted Burden of Care (BOC) Schedule and a Sociodemographic questionnaire. Results: The caregivers were 51% male and 49% female. Most were above 35years in age (66.1%). They were either parents (38.8%), siblings (18.4%), uncle/aunt (14.3%), first cousin (12.2%) or other extended relatives (16.3%). Almost half of the relatives had psychological distress (43.8%) and most of which (63%) had more burden. The mean score on the BOC among the caregivers was 41 (±18.68SD), with scores ranging from 0.00-89.00, and 45.3% of relatives experiencing more than average burden of care. Conclusion: There is a significant level of burden and psychological distress experienced by caregivers in this study location. It is recommended that effectively planned interventions are targeted at alleviating this burden and at improving the ability of caregivers to cope, within the Nigerian mental health service delivery system.

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Section: Burden Of Care (Boc) Schedulementioning

confidence: 99%

“…31 One is hopeful that the creation and use of locally based family support organizations may also be useful in the care of these relatives.…”

Section: Psychological Experiences In Care Givingmentioning

confidence: 99%

Burden and psychological effects : caregiver experiences in a psychiatric outpatient unit in Lagos, Nigeria

Oshodi¹,

Adeyemi²,

Aina³

et al. 2012

Afr. J. Psych

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“…SCD was also associated with delayed puberty. [28,51] Three studies from Nigeria reported the presence of overweight and obesity among patients with SCD although in lower proportions (an average of less than 3% of the sample population) [34,46,52].…”

Section: Resultsmentioning

confidence: 99%

Nutritional perspectives on sickle cell disease in Africa: A systematic review

Nartey

Spector

Adu‐Afarwuah

et al. 2021

Preprint

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Background: Sickle cell disease (SCD), an inherited blood disorder, predominantly affects individuals in sub-Saharan Africa. Research linking its pathophysiology and nutritional status in African patients has not been previously described. This systematic review aimed to assess the landscape of studies in sub-Saharan Africa focused on nutritional aspects of SCD and highlight gaps in knowledge that could inform priority-setting for future research.Methods: The study was conducted using the Preferred Reporting items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. All original studies involving individuals with any phenotypic variant of SCD and at least one nutritional status outcome; and were conducted between January 1995 and November 2020 in Africa were included. ‘Nutritional status’ was defined by studies on dietary intake, measurements of growth/anthropometry, or nutritional biomarkers. Studies were included if they involved Databases used were Ovid Embase, Medline, Biosis and Web of Science. Results: The search returned 526 articles with 76 studies included in the final analyses. Most investigations (67%) were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (49%), descriptive studies of macro- or micronutrient intakes (41%), and interventional studies (11%). Findings consistently found growth impairment, especially among children and adolescents from sub-Saharan Africa. Studies assessing macro- and micronutrients generally had small sample sizes and were exploratory in nature. Only four randomized trials were identified, which measured the impact of lime juice, long-chain fatty acids supplementation, ready-to-use supplementary food, and oral arginine on health outcomes. Conclusions: The findings reveal a moderate number of descriptive studies, most with small sample sizes, that focused on various aspects of nutrition and SCD in African patients. There was a stark lack of interventional studies that could be used to inform evidence-based changes in clinical practice. Findings of investigations were generally consistent with data from other regional settings, describing a significant risk of growth faltering and malnutrition among individuals with SCD. There is an unmet need for clinical research to better understand the potential benefits of nutritional-related interventions for patients with SCD in sub-Saharan Africa in order to promote optimal growth and improve health outcomes.

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“…[23,24,26] SCD was also associated with delayed puberty. [26,47] Three studies from Nigeria reported the presence of overweight and obesity among patients with SCD although in lower proportions (an average of less than 3% of the sample population). [30,42,48] Descriptive studies of macro-or micronutrient levels.…”

Section: Resultsmentioning

confidence: 99%

Nutritional Perspectives on Sickle Cell Disease in Africa: A Systematic Review

Nartey

Spector

Adu‐Afarwuah

et al. 2020

Preprint

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Background: Sickle cell disease (SCD), an inherited blood disorder, predominantly affects individuals in sub-Saharan Africa. While there are established studies that links its pathophysiology and nutritional status, the extent of research in this area involving African patients has not been previously described. This systematic review aimed to assess the nutrition-focused landscape of SCD studies in Africa, summarize findings, and highlight gaps in knowledge that could inform priority-setting for future research.Methods: The study was conducted using the Preferred Reporting items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We included all original studies, conducted between 1995 and 2018, on nutritional status of individuals with SCD in Africa. ‘Nutritional status’ was defined by studies on dietary intake, measurements of growth/anthropometry, and nutritional biomarkers. Studies of anemia in non-SCD individuals and those with sickle cell traits were excluded. Databases used were Ovid Embase, Medline, Biosis and Web of Science. Results: The search returned 366 articles from which 62 studies were included in the final analyses. Seventy percent of the investigations were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (50%), descriptive studies of macro- or micronutrient levels (35%), and interventional studies (15%). Findings consistently found growth impairment, especially among children and adolescents. Studies assessing macro- and micro-nutrients generally had small sample sizes and were exploratory in nature. Only two randomized placebo-controlled trials were identified, which measured the impact of fatty acid supplementation and lime juice on health outcomes. Conclusions: The findings reveal a moderate number of descriptive studies, with small sample size, that focused on various aspects of nutrition and sickle cell disease in African patients. There was a stark lack of interventional studies that could be used to inform evidence-based changes in clinical practice. Findings of investigations were generally consistent with data from other regional settings, describing a significant risk of growth faltering and malnutrition among individuals with SCD. There is an unmet need for clinical research to better understand the potential benefits of nutritional-related interventions for patients with SCD in sub-Saharan Africa in order to promote optimal growth and improve health outcomes.

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Sexual Maturation and Psychiatric Morbidity among Persons with Sickle Cell Anaemia in a Nigerian Teaching Hospital

Abstract: It is concluded that SCA subjects had significantly delayed sexual maturation and increased risk of psychiatric morbidity when compared to controls. The need for genetic counseling to reduce the prevalence of SCA was emphasized.

Cited by 6 publications

References 19 publications

Burden and psychological effects : caregiver experiences in a psychiatric outpatient unit in Lagos, Nigeria

Burden and psychological effects : caregiver experiences in a psychiatric outpatient unit in Lagos, Nigeria

Nutritional perspectives on sickle cell disease in Africa: A systematic review

Nutritional Perspectives on Sickle Cell Disease in Africa: A Systematic Review

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