Purpose: The purpose of this study was to investigate factors related to homosexual adolescents in South Korea. Methods: Using statistics from the 12th (2016) Korea Youth Risk Behavior Web-based Survey, hierarchical logistic regression analysis was conducted. The study sample comprised 65,528 middle and high school students aged 12 to 18 years. Results: The significant predictors of homosexual intercourse were gender, attempted suicide, bullying at school experience, ever drinking, ever smoking, habitual or purposeful drug use, cohabitation with family, weekly allowance, and mother’s education levels. Conclusions: The results suggest that gender-related interventions should be considered in school health education programs and that sexual health interventions for high-risk groups may be needed, given the factors predicting homosexual intercourse.