Sexual risk behaviour in a cohort of HIV-negative and HIV-positive Rwandan women

Mukanyangezi, MF; Manzi, Olivier; Tobin, Gunnar; Rulisa, Stephen; Bienvenu, Emile; Giglio, Daniel

doi:10.1017/s0950268818003023

Cited by 13 publications

(13 citation statements)

References 36 publications

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“…Previous diagnosis of other STDs and lack of knowledge of oneʼs own hepatitis status were also associated with risks of HIV infection among a small group of donors. While the latter might indicate lack of routine health care, previous diagnosis of other STDs is reported by multiple studies as a good indicator of high‐risk sexual behaviors . These results, combined with our findings about significant risks associated with MSM, multiple concurrent sex partners, having remunerated sex, and inconsistent use of condoms, highlight the importance of enhanced effort in educating the public on HIV transmission risks and the importance of safe sex practice in China.…”

Section: Discussionsupporting

confidence: 70%

Current risk factors for HIV infection among blood donors in seven Chinese regions

Zeng

Liu

Zhang³

et al. 2020

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BACKGROUND In China, there is a rising concern on the increasing trends of HIV infections in high‐risk groups, who make blood donations that might potentially challenge the blood safety. Analyses on current risk factors for HIV infection among Chinese blood donors are urgently needed for developing effective strategies to defer high‐risk donors and to warrant the safety of the blood supply. STUDY DESIGN AND METHODS We recruited 313 HIV‐positive and 762 HIV‐negative donors from seven study sites in China and evaluated donor demographic characteristics, current medical and behavioral risk factors associated with HIV infection in a case–control survey. Univariable analyses examined the relationship between HIV infection and donor and donation characteristics, medical and behavioral risks, living conditions, and lifestyles. Multivariable logistic regression analyses evaluated the association between selected individual risks and HIV infection. Regression tree analysis was used to select covariates correlated with both HIV infection and individual risks and thus need to be controlled for in logistic regression models. RESULTS Being a man who has sex with men was associated with the highest odds of HIV infection. Not using a condom, having sex with HIV‐infected individuals, having sex partners with sexually transmitted diseases (STDs), having more than two concurrent sex partners, or having an STD were all associated with more than five times higher odds of having HIV. Having remunerated sex was associated with a 2.4 increased odds of having HIV infection. CONCLUSION High‐risk sexual behaviors were among the major risks for HIV infection among Chinese blood donors.

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Section: Discussionsupporting

confidence: 70%

Current risk factors for HIV infection among blood donors in seven Chinese regions

Zeng

Liu

Zhang³

et al. 2020

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“…As the number of cases of individual STIs and RTIs was low, we did not attempt to stratify individual RTIs and STIs in the binary logistic regression analysis. However, as we showed in our previous studies , more unmarried than married women were HIV positive and differences in the prevalence of STIs and RTIs between HIV‐positive and HIV‐negative women exist, which may partly explain why being married was retained as an independent predictive factor for LSIL. Studies show that the risk of cervical cancer increases with the duration of use of oral contraceptives .…”

Section: Discussionmentioning

confidence: 69%

“…While Rwandan women generally reported having had only a few lifetime sexual partners , the number of HPV infections was high, particularly among HIV‐positive women. In our previous study , we also showed that other STIs, besides HIV infection, were common among HIV‐positive women even if they claimed to have used condoms during sexual activity or claimed not to have been engaged in sexual activity. A high rate of reported condom use among HIV‐positive individuals but a high rate of new STIs has also been demonstrated in other African countries .…”

Section: Discussionmentioning

confidence: 74%

“…The project was approved by the Institutional Review Board at the College of Medicine and Health Sciences, University of Rwanda and by the Ethics Committee at the University of Gothenburg. The demographics of the cohort have been described in our previous study . In brief, women followed in the study were 18 years and older and were enrolled in the study at the HIV clinic at the University Teaching Hospital of Kigali (CHUK; referred in the text as HIV+ women), at the outpatient gynaecology and obstetric clinics at CHUK and at the University Teaching Hospital of Butare (CHUB) in 2015.…”

Section: Methodsmentioning

confidence: 99%

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Persistence rate of cervical human papillomavirus infections and abnormal cytology in Rwanda

et al. 2019

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Objectives In this study, we determined the incidence and persistence of human papillomavirus (HPV) strains and of squamous intraepithelial lesions (SIL) or worse cytology in 237 HIV‐positive and HIV‐negative Rwandan women and whether the interleukin (IL)‐28B single nucleotide polymorphism (SNP) at rs12979860 correlated with susceptibility to and persistence of HPV infection. Methods Cervical samples were collected at baseline and after 9, 18 and 24 months for a 40‐HPV DNA screening test and a ThinPrep Pap test. Genotyping of the IL‐28B SNP rs12979860 was performed using real‐time polymerase chain reaction (PCR). Results Chronic high‐risk (HR) HPV infections occurred in 56% of HIV‐positive women, while no HIV‐negative women developed HPV chronicity. High‐grade SIL (HSIL) or cancer was diagnosed in 38% of HIV‐positive women with persistent HR‐HPV infections. HIV and HR‐HPV positivity at baseline were factors associated with an increased risk of HPV persistence. Additionally, HR‐HPV positivity at baseline was associated with an increased risk of developing HSIL or worse cytology. The unfavourable T/x genotype at rs12979860 is common among Africans, and women with this genotype were found to be more commonly infected with HPV. Conclusions HPV screening in Rwanda may help to identify women at risk of developing cervical cancer and polymorphism in IL‐28B may be associated with risk of contracting HPV infection.

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“…HIV-infected individuals through sexual route exhibited higher plasma HIV load and lower CD4 + T cell counts compared with those infected by blood transmission, resulting in a faster progression to AIDS among those infected by the sexual route [20]. Furthermore, HIV-infected individuals who were infected through sexual transmission may on the other hand have an increased risk of acquiring human papillomavirus, syphilis, candidiasis, herpes and genital ulcer disease [21, 22].…”

Section: Discussionmentioning

confidence: 99%

The factors associated with natural disease progression from HIV to AIDS in the absence of ART, a propensity score matching analysis

et al. 2020

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This study aimed at comparing the factors associated with the natural progression between typical progressors (TPs) and rapid progressors (RPs) in HIV-infected individuals. A retrospective study was conducted on 2095 eligible HIV-infected individuals from 1995 to 2016 in a high-risk area of Henan Province, China. Propensity score matching was used to balance covariates, and the conditional logistic regression analyses were performed to explore the factors of natural disease progression among HIV infectors. A total of 379 pairs of RPs and TPs were matched. The standardised difference values of all covariates were less than 10%. HIV-infected individuals transmitted through sexual transmission (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.36–0.85) were more likely to progress to AIDS compared with those infected through contaminated blood. Older age at diagnosis of HIV-infected individuals (OR 0.72, 95% CI 0.58–0.89) exhibited a faster progression to AIDS. HIV-infected individuals identified through a unique survey (OR 7.01, 95% CI 2.99–16.44) were less likely to progress to AIDS compared with those identified through medical institutions. HIV-infected individuals who had higher baseline CD4+T cell counts (OR 3.37, 95% CI 2.59–4.38) had a slower progression to AIDS. These findings provide evidence for natural disease progression from HIV to AIDS between TPs and RPs.

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Sexual risk behaviour in a cohort of HIV-negative and HIV-positive Rwandan women

Cited by 13 publications

References 36 publications

Current risk factors for HIV infection among blood donors in seven Chinese regions

Current risk factors for HIV infection among blood donors in seven Chinese regions

Persistence rate of cervical human papillomavirus infections and abnormal cytology in Rwanda

The factors associated with natural disease progression from HIV to AIDS in the absence of ART, a propensity score matching analysis

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