2024
DOI: 10.1186/s13293-024-00629-9
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Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta

Tania L. Gonzalez,
Bryn E. Willson,
Erica T. Wang
et al.

Abstract: Background Fetal sex and placental development impact pregnancy outcomes and fetal–maternal health, but the critical timepoint of placenta establishment in first trimester is understudied in human pregnancies. Methods Pregnant subjects were recruited in late first trimester (weeks 10–14) at time of chorionic villus sampling, a prenatal diagnostic test. Leftover placenta tissue was collected and stored until birth outcomes were known, then DNA and R… Show more

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