2013
DOI: 10.1016/j.brainres.2013.04.060
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Sexually dimorphic intracellular responses after cocaine-induced conditioned place preference expression

Abstract: Sex differences in cocaine’s mechanisms of action and behavioral effects have been widely reported. However, little is known about how sex influences intracellular signaling cascades involved with drug-environment associations. We investigated whether ERK/CREB intracellular responses in the mesocorticolimbic circuitry underlying cocaine environmental associations are sexually dimorphic. We used a standard 4 day conditioned place preference (CPP) paradigm using 20mg/kg cocaine—a dose that induced CPP in male an… Show more

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Cited by 18 publications
(12 citation statements)
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“…However, NAc pERK levels, but not pCREB levels, during the post-test were positively correlated with CPP scores. These data are consistent with previous studies showing that NAc ERK phosphorylation is associated with cocaine CPP [5] [7] [9] [11] [12] [40]. Here, we extend these results and show that during CPP expression, different patterns of intracellular signaling responses in the NAc and CPu emerge based on whether or not cocaine-CPP behavior has been acquired/expressed.…”
Section: Discussionsupporting
confidence: 92%
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“…However, NAc pERK levels, but not pCREB levels, during the post-test were positively correlated with CPP scores. These data are consistent with previous studies showing that NAc ERK phosphorylation is associated with cocaine CPP [5] [7] [9] [11] [12] [40]. Here, we extend these results and show that during CPP expression, different patterns of intracellular signaling responses in the NAc and CPu emerge based on whether or not cocaine-CPP behavior has been acquired/expressed.…”
Section: Discussionsupporting
confidence: 92%
“…The place preference apparatus (purchased from Med Associates, Georgia, VT) previously described [7] [9] [36] consisted of a rectangular cage with three chambers: 2 square conditioning chambers (28cm in length) separated by a neutral rectangular chamber (12cm long and 4cm wide). The two conditioning chambers were differentiated by tactile and visual cues; in one, the floor was a stainless steel mesh and the walls were white, and in the other, the floor was made up of a grid of stainless steel rods and the walls were black.…”
Section: Methodsmentioning
confidence: 99%
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“…The aim of the present study was to determine the extent to which increases in phosphorylated protein levels previously observed after cocaine-CPP expression (Nygard et al, 2013), are context-induced. Consistent with our hypothesis, drug-free re-exposure to the environment paired with cocaine during CPP training context dependently increased NAc pERK levels when compared to animals re-exposed to the control environment.…”
Section: Discussionmentioning
confidence: 99%
“…A three chamber place preference apparatus (Med Associates, Georgia, VT, USA), was used as previously described (Russo et al, 2003; Nygard et al, 2013). Briefly, a rectangular neutral chamber with gray walls and a smooth PVC floor separated two square conditioning chambers with distinct visual and tactile cues.…”
Section: Methodsmentioning
confidence: 99%