Sexually Transmitted Infections and Contraceptive Use in Adolescents

Derefinko, Karen J.; Ashby, Sydney; Hayes, Tristan; Kaplan, Cameron M.; Bursac, Zoran; García, Francisco I. Salgado; Madjlesi, Amy F.; Tonkin, Leah; Bowden, Michelle; Popescu, Filoteia; Waters, Teresa M.

doi:10.1016/j.amepre.2019.11.012

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…84,85 However, in two recent longitudinal studies evaluating STI incidence in users of difference contraceptive methods in sub-Saharan African women and US adolescents, respectively, Cu-IUD use was a significant risk factor for trichomoniasis. 88,90,91…”

Section: Observational Studiesmentioning

confidence: 99%

“…Here, contraceptive IVR use was found to be a risk factor for genital herpes. 90 Given the possibility that sex hormones may alter T cell immunity, 112 observational studies have explored the association between HCs and HSV shedding with conflicting results. [113][114][115]…”

Section: Herpes Simplex Virusmentioning

confidence: 99%

“…41,42 One recent study, conducted in US adolescents, found contraceptive IVR use to be a significant risk factor for HPV acquisition. 90 The available observational evidence does not support an association between DMPA-IM use and HPV acquisition risk and clearance, although injectable contraceptive users may have increased risk of persistent HPV infection. 41,42 Data on HPV acquisition, persistence and/or clearance among implant and IUD users are sparse 41,42 and the results mixed.…”

Section: Human Papillomavirusmentioning

confidence: 99%

“…Very few studies have evaluated implant, contraceptive IVR and IUD use on bacterial STI risk and generally, no association has been found 84,85 . However, in two recent longitudinal studies evaluating STI incidence in users of difference contraceptive methods in sub‐Saharan African women and US adolescents, respectively, Cu‐IUD use was a significant risk factor for trichomoniasis 88,90,91 …”

Section: Impact Of Contraceptives On the Vaginal Microbial Communitymentioning

confidence: 99%

See 3 more Smart Citations

Contraceptive effects on the cervicovaginal microbiome: Recent evidence including randomized trials

Balle,

Happel,

Heffron

et al. 2023

American J Rep Immunol

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BackgroundUntil recently, most data regarding the effects of non‐barrier contraceptives on the mucosal microbiome have derived from observational studies, which are potentially biased due to behavioral confounders that may mask their true biological effects.Method of StudyThis narrative review summarises recent evidence of the effect of contraceptives on the cervicovaginal microbiome, emphasising data obtained through randomized trials.ResultsGood quality data describe that initiation of long‐acting progestin‐only contraceptives, including levonorgestrel (LNG)‐implant and the injectables depot‐medroxyprogesterone acetate (DMPA‐IM) and norethisterone enanthate (NET‐EN) do not alter the mucosal microbial environment. Likewise, no strong evidence exists that the use of oral contraceptive pills (OCPs) is associated with alterations of the vaginal microbiome or increased risk of bacterial sexually transmitted infections (STIs). Limited data on the effect of intravaginal rings (IVRs) on the mucosal environment exist and show conflicting effects on the vaginal microbiota. Copper intrauterine device (Cu‐IUD) initiation has been associated with bacterial vaginosis (BV) acquisition, including in a randomized trial. LNG‐IUDs may have similar affects but need to be evaluated further.ConclusionDifferent synthetic hormones have divergent effects on the microbiome and therefore novel hormonal methods need to be rigorously evaluated. Furthermore, the addition of antiretrovirals into multipurpose technologies may alter the effects of the hormonal component. There is thus a critical need to improve our understanding of the biological effects of contraceptive hormones and delivery methods with different pharmacokinetic and chemical properties on the mucosal microbiome in rigorous trials, to inform the development of novel contraceptives and improve individual family planning guidance.

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Section: Observational Studiesmentioning

confidence: 99%

Section: Herpes Simplex Virusmentioning

confidence: 99%

Section: Human Papillomavirusmentioning

confidence: 99%

Section: Impact Of Contraceptives On the Vaginal Microbial Communitymentioning

confidence: 99%

See 2 more Smart Citations

Contraceptive effects on the cervicovaginal microbiome: Recent evidence including randomized trials

Balle,

Happel,

Heffron

et al. 2023

American J Rep Immunol

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show abstract

“…Apart from these devices intended to be used during surgery, other medical devices including ancillary medicinal substances are targeted at the end-user. This is the case of medicated condoms, whose principal intended action of preventing pregnancy, as well as the transmission of sexually transmitted infections, is achieved by the physical barrier provided by the device, while the action of the medicinal substance (palliating the effects of premature ejaculation) is ancillary to that of the device (Beksinska et al, 2020;Derefinko et al, 2020). Even though their efficacy in comparison with regular condoms has not been tested in controlled trials, the theoretical benefits of incorporating an anaesthetic drug, such as benzocaine, have been enough to promote the use of these devices (Butcher et al, 2020).…”

Section: Examples Of Medical Devices With An Ancillary Medicinal Subs...mentioning

confidence: 99%

The combination of medical devices and medicinal products revisited from the new European legal framework

Antich-Isern

Caro-Barri

Aparicio-Blanco

2021

International Journal of Pharmaceutics

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Long-Acting Reversible Contraception, Condom Use, and Sexually Transmitted Infections: A Systematic Review and Meta-analysis

Steiner

Pampati²,

Kortsmit

et al. 2021

American Journal of Preventive Medicine

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Sexually Transmitted Infections and Contraceptive Use in Adolescents

Cited by 7 publications

References 8 publications

Contraceptive effects on the cervicovaginal microbiome: Recent evidence including randomized trials

Contraceptive effects on the cervicovaginal microbiome: Recent evidence including randomized trials

The combination of medical devices and medicinal products revisited from the new European legal framework

Long-Acting Reversible Contraception, Condom Use, and Sexually Transmitted Infections: A Systematic Review and Meta-analysis

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