Sexually transmitted infections and viral hepatitides in patients presenting for non-occupational HIV post-exposure prophylaxis: results of a prospective cohort study

Abstract

Data evaluating the screening practices for viral hepatitides and sexually transmitted infections (STIs) in patients presenting for non-occupational HIV post-exposure prophylaxis (nPEP) care are limited. Screening practices and prevalences of viral hepatitides and STIs were evaluated in 126 patients presenting to a dedicated HIV prevention clinic for HIV nPEP. Three patients (2.4%) were diagnosed with chronic hepatitis C infection, 28 (22.2%) did not have surface antibodies in sufficient quantity to confer immunity to hepatitis B, and six (4.8%) were diagnosed with an STI. A multivariate regression model did not predict any demographic or clinical features predictive of HBV non-immunity. Beyond screening for HIV infection, evaluation for viral hepatitides and STIs is an important feature in the care of patients presenting for HIV nPEP.

Randomized controlled trial of the tolerability and completion of maraviroc compared with Kaletra® in combination with Truvada® for HIV post-exposure prophylaxis (MiPEP Trial)

“…Although proximal renal tubular dysfunction and Fanconi's syndrome are well reported in HIVpositive individuals on TDF-based ART [30], these have not been reported in the setting of PEP and were not seen in this study.…”

Optimal HIV Postexposure Prophylaxis Regimen Completion With Single Tablet Daily Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine Compared With More Frequent Dosing Regimens

“…These individuals could be excellent candidates for PrEP, and optimally managing the PEP-PrEP transition should be an important part of ongoing clinical education for successful HIV prevention (33,38). By determining the likelihood of recurring risk, providers can use a satisfactory PEP experience as an opportunity to educate their patients about the need for consistent adherence if the patients are to transition to a PrEP regimen that will need to be taken over a sustained period of time in order to be effective for long-term protection against HIV.…”

Nonoccupational Postexposure Prophylaxis (nPEP) Visits: Opportunities Beyond HIV PEP

“…For these reasons, the study by Sivachandran and colleagues in this edition of the International Journal of Infectious Diseases is a welcome addition to the nPEP literature. 1 The authors prospectively followed 126 individuals who presented to a dedicated HIV prevention clinic after a nonoccupational exposure (approximately 70% were sexual exposures). The analysis concentrates on screening practices, diagnosis rates, and follow-up for bacterial STI's and viral hepatitis, and provides several notable findings.…”