Human have been affected by their geographical surroundings and influenced their surroundings with the transition to settled life. The Güzelhisar river coastal plain is one of the places that have good examples of the natural environment change-human interaction from the Middle Holocene. The plain and the shoreline progressed from the interior to the present during the Holocene. This change has affected the archeological settlements such as Myrina, Tisna and Çaltılıdere in the vicinity of the plain. In order to determine the paleogeography of the plain and its effect on these settlements in the surrounding area, 35 core drillings was carried out and grain size, element, microfossil analyzes of drilling samples were made. Microfossil analyzes were used to identify coastal marshes, lagoons and marine environments. As a result of the studies made, the alluvium layers of the ovary were classified by separating 6 alluvial deposits according to the environments they reflect. According to this classification and dates, the development of the Güzelhisar coastal plain and deltas during the last 6500-7000 years (along with Holocene transgression-from the Middle Holocene) has been determined according to the changing coastal lines. Geoarchaeological interpretations of the archaeological embellishments such as Myrina, Tisna and Çaltılıdere affected by the changing natural landscape have been made. Geoarchaeological interpretations of archeological settlements such as Myrina, Tisna and Çaltılıdere affected by the changing natural landscape were made. It was reaffirmed by microfossil analysis that the settlement of Myrina's ancient city had begun 3000 thousand years ago with the existence of a narrow shallow and narrow throat that the other hill (kalabasar hill) is an island 4000 years ago today. Beside this, it was determined that Sarıkaya Depression was connected to the depression of Güzelhisar in Çaltılıdere Bay with a shallow marine channel 6000-6500 years ago. This channel, formed by Holocene transgression, was filled up and became into a land in a short time. The Çaltildere settlement in this area should also be established with the Middle Bronze Age. It is understood that the city of Tisna, on the other hand, is located on a ridge 1-2 km away from the shore even during the most intrusive period of the sea by the Holocene transgression. In the depression of Güzelhisar Creek, in the natural sediments of the coastline during the period when the sea was most intruded archaeological deposits belonging to an ancient settlement where was closer was determined.