Sezary Cell Lymphoma Following Cyclosporin Immunosuppression for Renal Transplantation

Tomson, Charles; Graham, S.; Hutchinson, Robert; Flower, A. J. E.; Edmunds, Matthew R.; Feehally, John

doi:10.1093/ndt/6.11.896

Cited by 10 publications

(7 citation statements)

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“…ALCL is most common form of T‐cell‐associated PTLD. Furthermore, as with the majority of other reported cases of T‐cell‐associated PTLD, a direct role for EBV in lesional propagation could not be demonstrated in either case; 16–36 in a minority of cases of post‐transplant ALCL, localization of EBV within the neoplastic cell population has been identified. Cutaneous B‐cell PTLD typically develop several years after the solid organ transplant.…”

Section: Discussionmentioning

confidence: 65%

Post‐transplant EBV‐negative anaplastic large‐cell lymphoma with dual rearrangement: a propos of two cases and review of the literature

et al. 2007

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Section: Discussionmentioning

confidence: 65%

Post‐transplant EBV‐negative anaplastic large‐cell lymphoma with dual rearrangement: a propos of two cases and review of the literature

et al. 2007

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“…[6][7][8][9][10][11] All cases followed renal transplantation, with one following renal and pancreatic transplantation. No EBV virus was detected in the four cases that were studied.…”

Section: Discussionmentioning

confidence: 99%

Primary ???Cutaneous??? T-Cell Anaplastic Large Cell Lymphoma, CD30+, Neutrophil-Rich Variant with Subcutaneous Panniculitic Lesions, in a Post-Renal Transplant Patient

Salama

2005

The American Journal of Dermatopathology

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Posttransplantation lymphoproliferative disorders (PTLD) presenting clinically in the skin are rare and usually of B-cell phenotype. Only 7 cases of cutaneous T-cell PTLD have been previously reported, mostly mycosis fungoides type, with no known cases of "cutaneous" presentation by CD30 (Ki-1) anaplastic large cell lymphoma (ALCL). The case reported is a 59-year-old male who developed multiple skin nodules on the right leg, 6 years following renal transplantation. Initial biopsy showed ALCL involving the dermis with a background rich in neutrophils. The neoplastic cells were of T-cell phenotype, strongly CD30 with typical staining, and BCL-2 positive, but P53 negative. No EBV was detected by IHC, ISH, or DNA analysis. One year later, he developed painful subcutaneous nodules with surrounding erythema, resembling deep pustules or panniculitis, which on biopsy showed preferential involvement of the subcutaneous fat and prominent component of neutrophils. Twenty-two months following diagnosis, he died of cardiac failure with terminal myocardial infarct. There was however no clinical evidence of systemic spread of the lymphoma.This report adds to the clinical and morphologic spectrum of these rare "cutaneous" lymphomas of T-cell lineage arising in the posttransplantation setting, and suggests that EBV does not play a role in their pathogenesis.

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“…[51] The majority of reports of post-transplant lymphoproliferative disorder correspond to mycosis fungoides, Sezary syndrome, or cutaneous T-cell lymphoma. [52][53][54][55] EBV has been implicated in the pathogenesis of post-transplant lymphoproliferative disorder; however, the presence of the virus has not been documented in all cases.…”

Section: Post-transplant Lymphoproliferative Disordermentioning

confidence: 99%

Mucocutaneous Manifestations of Epstein-Barr Virus Infection

Mendoza

Diamantis

Arora

et al. 2008

American Journal of Clinical Dermatology

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This review focuses on Epstein-Barr virus (EBV) infection, diagnosis, and current treatment, with emphasis on EBV-associated mucocutaneous manifestations in primary infections, acute EBV-associated syndromes, chronic infections, lymphoproliferative disorders, and lymphomas. In primary infection, EBV infects B cells and can cause mucocutaneous manifestations in infectious mononucleosis or acute EBV-associated syndromes such as Gianotti-Crosti syndrome and hemophagocytic syndrome. EBV then persists in the majority of humans generally without causing disease. In some cases, however, latent EBV infection may result in diseases such as hydroa vacciniforme, hypersensitivity to mosquito bites, and lymphoproliferative disorders such as plasmablastic lymphoma, oral hairy leukoplakia, and post-transplant lymphoproliferative disorders, particularly in immunocompromised patients. Latent EBV infection has also been implicated in a variety of malignant conditions such as Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, and Kikuchi histocytic necrotizing lymphadenitis. Since the immune system is critical in preventing the progression of EBV disease, the immunologic status of the patient plays a crucial role in the subsequent development of pathologies.

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Sezary Cell Lymphoma Following Cyclosporin Immunosuppression for Renal Transplantation

Cited by 10 publications

References 0 publications

Post‐transplant EBV‐negative anaplastic large‐cell lymphoma with dual rearrangement: a propos of two cases and review of the literature

Post‐transplant EBV‐negative anaplastic large‐cell lymphoma with dual rearrangement: a propos of two cases and review of the literature

Primary ???Cutaneous??? T-Cell Anaplastic Large Cell Lymphoma, CD30+, Neutrophil-Rich Variant with Subcutaneous Panniculitic Lesions, in a Post-Renal Transplant Patient

Mucocutaneous Manifestations of Epstein-Barr Virus Infection

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