Sézary syndrome: A study of 176 patients at Mayo Clinic

Peripheral Neuropathy in Sézary Syndrome: Coincidence or a Part of the Syndrome?

“…Neuronal antigens expressed by the tumor stimulate an immune response characterized by T cells, antibodies, or both, which attack not only the tumor but also the neural tissue [8]. Although these scenarios could be expected in lymphomas, nervous system involvement is not commonly reported in reviews of SS [1,2]. …”

Cutaneous lymphomas: A review

“…Patients may complain of intense pruritus, weight loss, fevers, and chills. These clinical findings are nonspecific, and they are also found in varying frequencies in erythrodermic patients with different etiologies, highlighting the importance of extensive laboratory research seeking to determine the cutaneous and blood involvement of neoplastic cells in erythrodermic patients [44][45][46] . The prognosis of SS is poor, with a median survival of four years after diagnosis (or 42.3% at five years) 45 .…”

“…These clinical findings are nonspecific, and they are also found in varying frequencies in erythrodermic patients with different etiologies, highlighting the importance of extensive laboratory research seeking to determine the cutaneous and blood involvement of neoplastic cells in erythrodermic patients [44][45][46] . The prognosis of SS is poor, with a median survival of four years after diagnosis (or 42.3% at five years) 45 . The main prognostic factors include age at diagnosis and tumor burden, as measured by LDH levels, the CD4/CD8 ratio, and the absolute Sézary cell count 47 .…”

Rare Lymphomas

“…Like in MF, there is an approximately 1.6:1 preponderance for males and unlike MF caucasians are more likely to be affected than individuals of colored skin (Kubica et al 2012 ). Like in MF, there is an approximately 1.6:1 preponderance for males and unlike MF caucasians are more likely to be affected than individuals of colored skin (Kubica et al 2012 ).…”