SF-1 is a Diagnostically Useful Immunohistochemical Marker and Comparable to Other Sex Cord-Stromal Tumor Markers for the Differential Diagnosis of Ovarian Sertoli Cell Tumor

Zhao, Chengquan; Barner, Ross; Vinh, Tuyethoa N.; McManus, Kim; Dabbs, David J.; Vang, Russell

doi:10.1097/pgp.0b013e31817c1b0a

Cited by 73 publications

(47 citation statements)

References 30 publications

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“…140 Markers that are useful to distinguish between an endometrioid neoplasm and a sex cord-stromal tumour include inhibin, calretinin and steroidogenic factor-1 (SF-1; positive in sex cord-stromal tumours) and epithelial membrane antigen and CK7 (positive in epithelial neoplasms). [120][121][122][140][141][142] Diagnosis of STIC. Biomarkers are not necessary if the features are unequivocally those of STIC but if there is diagnostic uncertainty, both p53 and MIB1 staining should be performed.…”

Section: Immunohistochemical Markersmentioning

confidence: 99%

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

et al. 2015

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Section: Immunohistochemical Markersmentioning

confidence: 99%

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

et al. 2015

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“…204,205 FOXL2 is also reported in female adnexal tumor of wolffian origin (FATWO) and 50% of Sertoli-Leydig cell tumors. 204 SF-1 is another promising nuclear stain with reported positivity in all adult and juvenile granulosa cell tumors 194,202 and most fibromas, thecomas, Sertoli cell tumors, and steroid cell tumors 202,206 and reported negativity in yolk sac tumors, 194 carcinoid tumors, and primary and metastatic ovarian carcinomas. 206,207 WT1 stains positively in most cases of granulosa cell tumor and sex cord-stromal tumors.…”

Section: Sex Cord-stromal Tumorsmentioning

confidence: 99%

“…204 SF-1 is another promising nuclear stain with reported positivity in all adult and juvenile granulosa cell tumors 194,202 and most fibromas, thecomas, Sertoli cell tumors, and steroid cell tumors 202,206 and reported negativity in yolk sac tumors, 194 carcinoid tumors, and primary and metastatic ovarian carcinomas. 206,207 WT1 stains positively in most cases of granulosa cell tumor and sex cord-stromal tumors. 196,202,208 CD56 stains positively in granulosa cell tumor but its use is limited owing to its expression in a large variety of mimics including small cell carcinoma, large cell neuroendocrine carcinoma, fibrothecoma, endometrioid and serous carcinomas, and endometrial stromal sarcomas.…”

Section: Sex Cord-stromal Tumorsmentioning

confidence: 99%

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The Utility of Immunohistochemistry in the Differential Diagnosis of Gynecologic Disorders

Kaspar

Crum

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context Immunohistochemistry has assumed an increasing role in the identification and characterization of gynecologic disorders including lesions with deceptively bland morphology, uncommon and underdiagnosed neoplasms, and neoplasms with specific genetic alterations associated with overexpression or loss of expression of specific proteins. The diagnostic accuracy has been significantly improved owing to the discovery and increasing experience with the tumor-associated biomarkers, and the increasing demand for precise tumor classification to assess suitability for the expanding therapeutic modalities including clinical trials. Objective To differentiate lesions of the gynecologic tract through the use of effective immunohistochemical panels. Data Sources Literature review and authors' personal practice experience. Conclusions The application of diagnostic and prognostic immunohistochemical panels has enabled pathologists to better guide therapeutic decisions and to better predict the clinical outcome. It is now well established that the use of ancillary testing, including immunohistochemistry, has a significant power in the identification, differentiation, and classification of reactive, premalignant, and malignant gynecologic disorders. This article discusses the utilities and pitfalls of the commonly used immunohistochemical markers in the context of overlapping morphologic features encountered in the uterus, ovaries, and fallopian tubes.

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“…SF-1 is an orphan nuclear receptor that regulates the transcription of an array of genes involved in reproduction, steroidogenesis, and male sexual differentiation. SF-1 amplification and overexpression are found in various tumors (39)(40)(41). IFN-Ïs were found to inhibit tumor growth in vitro and in vivo (12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Integrative genomic analyses on interferon-λs and their roles in cancer prediction

Yang

Wei²,

He³

2009

Int J Mol Med

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Abstract. Interferon (IFN)-Ïs, including IFN-Ï1, IFN-Ï2, and IFN-Ï3, are a newly described group of cytokines distantly related to the type I IFNs and IL-10 family members. Besides the antiviral activity, IFN-Ïs were reported to inhibit various tumor growths in vitro and in vivo. Herein, we identified IFN-Ï genes from the genome sequences of the human, chimpanzee, macaque, orangutan, mouse, rat and dog, and found that the locations and copy of a specific IFN-Ï varied in different genomes, not just the copy of IFN-Ïs. We found human IFN-Ïs were expressed in fetal retina, fetal brain and T cells by ESTs search. Moreover, IFN-Ïs were also found to express in bladder cancer, blood cancer, breast cancer, glioma, head and neck cancer and lung cancer tissues. Three tumorrelated transcriptional factors (steroidogenic factor-1, Wilms tumor 1 and P53) binding sites were identified within the 1.0-kb regions upstream of the transcriptional start site of human IFN-Ïs. Meta-analysis of the prognostic value of IFN-Ï genes in various cancers showed that the expression of IFN-Ïs are indeed related to the cancer prognosis in certain types of cancer. It can be predicted that IFN-Ïs take part in the cancer development by the regulation of expression of IFN-Ïs related to the SF-1, P53 and WT-1.

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SF-1 is a Diagnostically Useful Immunohistochemical Marker and Comparable to Other Sex Cord-Stromal Tumor Markers for the Differential Diagnosis of Ovarian Sertoli Cell Tumor

Cited by 73 publications

References 30 publications

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

The Utility of Immunohistochemistry in the Differential Diagnosis of Gynecologic Disorders

Integrative genomic analyses on interferon-λs and their roles in cancer prediction

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