In this paper, the age factor of chloride diffusion coefficient of concrete is considered, as well as the randomness of the chloride diffusion coefficient, concrete cover depth, surface concentration, threshold concentration and age factor. Based on the First Order Reliability Method, a time-dependent reliability analysis model for concrete structures under chloride conditions is established. The results show that the time-dependent reliability model is in good agreement with the Monte Carlo sampling method. The results of example show that the corner region of the concrete structure must be designed and calculated based on the two-dimensional diffusion model, and the attenuation characteristics and randomness must be considered for the concrete structures in chloride environment.