2020
DOI: 10.21203/rs.3.rs-119093/v1
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SFRP1 and PTGS2 are potential biomarkers of tumorigenic properties in human placenta-derived mesenchymal stem cells

Abstract: Background Mesenchymal stem cells (MSCs) display tumour tropism and have been explored as cellular vehicles to deliver anti-cancer agents. As cellular components of the tumour microenvironment, MSCs also influence tumour progression. However, the tumour transformation-related genes of MSCs are not well understood since either oncogenic or tumour suppressor effects within these cells have been reported. Here, we aimed to identify potential biomarkers capable of tumorigenic risk by RNA-seq analysis of human pla… Show more

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