SFTSV infection in rodents and their ectoparasitic chiggers

Gu, Xun; Su, Wen-Qing; Zhou, Chuan-Min; Fang, Li-Zhu; Zhu, Kun Yan; Ma, Dongqiang; Jiang, Fachun; Li, Zemin; Li, Dan; Duan, Shu-Hui; Peng, Qiu-Ming; Wang, Rui; Jiang, Yuan; Han, Hui-Ju; Yu, Xue Jie

doi:10.1371/journal.pntd.0010698

Cited by 10 publications

(4 citation statements)

References 42 publications

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“…agrarius in the ROK. Our results were significantly lower than those reported in China (32.3%) [ 119 ]. Compared with the infection rates reported in other animals in the ROK, the prevalence of SFTSV in rodents was similar to that in wild boars (5.2%) [ 120 ] and ticks (6.0%) [ 121 ], but higher than that in cats (4.0%) [ 122 ], dogs (2.9%) [ 123 ], pigs (1.7%) [ 124 ], black goats (2.4%) [ 125 ], and wild animals (3.3%) [ 126 ].…”

Section: Discussioncontrasting

confidence: 99%

Molecular surveillance of zoonotic pathogens from wild rodents in the Republic of Korea

Choi,

Hwang,

Kim

et al. 2024

PLoS Negl Trop Dis

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Background Rodents are recognized as major reservoirs of numerous zoonotic pathogens and are involved in the transmission and maintenance of infectious diseases. Furthermore, despite their importance, diseases transmitted by rodents have been neglected. To date, there have been limited epidemiological studies on rodents, and information regarding their involvement in infectious diseases in the Republic of Korea (ROK) is still scarce. Methodology/Principal findings We investigated rodent-borne pathogens using nested PCR/RT-PCR from 156 rodents including 151 Apodemus agrarius and 5 Rattus norvegicus from 27 regions in eight provinces across the ROK between March 2019 and November 2020. Spleen, kidney, and blood samples were used to detect Anaplasma phagocytophilum, Bartonella spp., Borrelia burgdorferi sensu lato group, Coxiella burnetii, Leptospira interrogans, and severe fever with thrombocytopenia syndrome virus (SFTSV). Of the 156 rodents, 73 (46.8%) were infected with Bartonella spp., 25 (16.0%) with C. burnetii, 24 (15.4%) with L. interrogans, 21 (13.5%) with A. phagocytophilum, 9 (5.8%) with SFTSV, and 5 (3.2%) with Borrelia afzelii. Co-infections with two and three pathogens were detected in 33 (21.1%) and 11 rodents (7.1%), respectively. A. phagocytophilum was detected in all regions, showing a widespread occurrence in the ROK. The infection rates of Bartonella spp. were 83.3% for B. grahamii and 16.7% for B. taylorii. Conclusions/Significance To the best of our knowledge, this is the first report of C. burnetii and SFTSV infections in rodents in the ROK. This study also provides the first description of various rodent-borne pathogens through an extensive epidemiological survey in the ROK. These results suggest that rodents harbor various pathogens that pose a potential threat to public health in the ROK. Our findings provide useful information on the occurrence and distribution of zoonotic pathogens disseminated among rodents and emphasize the urgent need for rapid diagnosis, prevention, and control strategies for these zoonotic diseases.

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Section: Discussioncontrasting

confidence: 99%

Molecular surveillance of zoonotic pathogens from wild rodents in the Republic of Korea

Choi,

Hwang,

Kim

et al. 2024

PLoS Negl Trop Dis

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“…Rodents are one of the hosts of the ticks, and their SFTSV positivity rate is higher than that of any other animal species [ 37 ]. Liu et al [ 38 ] demonstrated that SFTSV seropositivity in house mice and striped field mice was higher than that in other rodent species.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics and Risk Factors of Severe Fever With Thrombocytopenia Syndrome in Yantai City, Shandong Province

Hou¹,

Zhang²,

Liu³

et al. 2023

Open Forum Infectious Diseases

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Background To better understand the epidemiological characteristics and risk factors associated with the incidence of severe fever with thrombocytopenia syndrome (SFTS) in Yantai City, Shandong Province, China. Methods The SFTS data from 2010 to 2019 were obtained from the National Notifiable Disease Reporting System, and visualization was performed using ArcGIS 10. A community-based, 1:2 matched case-control study was conducted to investigate the risk factors for SFTS in Yantai City. Standardized questionnaires were used to collect detailed information about the demographics and risk factors for SFTSV infection. Results A total of 968 laboratory-confirmed SFTS cases were reported, 155 (16.01%) of which were fatal. The SFTS epidemic curve revealed that most cases occurred from May to August, accounting for 77.27% of all studied cases. The SFTS cases were mainly distributed in Lai Zhou, Penglai, Zhaoyuan, Haiyang, and Qixia from 2010 to 2019 (accounting for 83.47% of all cases). No differences in demographics were observed between the cases and controls. In the multivariate analysis, presence of rats in the household (OR=2.89, 95%CI=1.94-4.30), bitten by the ticks one month before the onset of symptoms (odds ratio [OR]=15.97, 95% confidence interval [CI]=5.36-47.60), and presence of weeds and shrubs around the house (OR=1.70, 95%CI=1.12-2.60) were found to be the risk factors for SFTS. Conclusions Our results support the hypothesis that ticks are important vectors of the SFTS virus. Education on SFTS prevention and personal hygiene should be imparted in high-risk populations, especially among outdoor workers living in SFTS-endemic areas, while vector management should also be considered.

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“…SFTS is often characterized by acute fever accompanied with thrombocytopenia and leukocytopenia, which can cause bleeding and severe consequences, with a mortality rate as high as 30% ( Yu et al., 2011 ). SFTSV was first identified in China in 2010 and since then has been reported in Japan, South Korea, Myanmar, Vietnam, and Thailand ( Gu et al., 2022 ). SFTS is usually transmitted through tick bites, with the Asian longhorned tick ( Hemaphysalis longicornis ) as the main vector ( Tufts et al., 2021 ; Rochlin et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Hsp90 β is critical for the infection of severe fever with thrombocytopenia syndrome virus

Wang,

Zhang,

Deng

et al. 2024

Virologica Sinica

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SFTSV infection in rodents and their ectoparasitic chiggers

Cited by 10 publications

References 42 publications

Molecular surveillance of zoonotic pathogens from wild rodents in the Republic of Korea

Molecular surveillance of zoonotic pathogens from wild rodents in the Republic of Korea

Epidemiological Characteristics and Risk Factors of Severe Fever With Thrombocytopenia Syndrome in Yantai City, Shandong Province

Hsp90 β is critical for the infection of severe fever with thrombocytopenia syndrome virus

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