Shade gardens / by Oliver E. Allen and the editors of Time-Life Books.

Allen, Oliver E.

doi:10.5962/bhl.title.39857

Cited by 4 publications

(4 citation statements)

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“…ColDx (Almac Group Ltd, Craigavon, U.K., http://www. almacgroup.com) was developed as a 634-gene signature from 215 stage II patients using FFPE tissue and analyzed using the Almac Dx colorectal cancer disease-specific array [31,32]. Multivariate analysis included tumor stage, grade, location, patient age and gender, mucinous type, lymphovascular invasion, and number of lymph nodes examined, but microsatellite instability status was not included.The study included a training set from 142 low-risk and 73 high-risk patients, and an independent validation set of 144 patients enriched for recurrence included 85 low-risk and 59 high-risk patients.…”

Section: Gene Expression Profilingmentioning

confidence: 99%

Identification of Clinically Relevant Molecular Subtypes in Colorectal Cancer: The Dawning of a New Era

Johnston

2014

The Oncologist

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In recent years, a number of protein and genomic‐based biomarkers have begun to refine the prognostic information available for colorectal cancer (CRC) and predict defined patient groups that are likely to benefit from systemic treatment or targeted therapies. Of these, KRAS represents the first biomarker integrated into clinical practice for CRC. Microarray‐based gene expression profiling has been used to identify prognostic signatures and, to a lesser extent, predictive signatures in CRC. Despite these advances, a number of major challenges remain. This article, which is based on a lecture delivered as part of the 2013 Bob Pinedo Cancer Care Prize, reviews the impact of molecular biomarkers on the management of CRC, emphasizing changes that have occurred in recent years, and focuses on potential mechanisms of patient stratification and opportunities for novel therapeutic development based on enhanced biological understanding of colorectal cancer.

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Section: Gene Expression Profilingmentioning

confidence: 99%

Identification of Clinically Relevant Molecular Subtypes in Colorectal Cancer: The Dawning of a New Era

Johnston

2014

The Oncologist

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“…posit that management has some discretion in the choice of organizational form (Allen, 1979;Child, 1972).…”

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confidence: 99%

The Adoption of the Multidivisional Form of Organization: A Contingency Model*

Mahoney

1992

J Management Studies

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“…Attempts in the 1970s to establish socio‐biology spurred intense controversies, and were attacked for joining the long line of biological determinists. “The reason for the survival of these recurrent determinist theories”, argued its critics, “is that they consistently tend to provide a genetic justification of the status quo and of existing privileges for certain groups according to class, race or sex” (Allen et al 1975). That discussion became polarized to the extreme in cases when sociologists and biologists would reject all attempts to explain human identity and social life in any terms other than their own.…”

Section: Broadening the Perspective: Epigenetic Proaction And Ideologmentioning

confidence: 99%

The Culture‐Bound Brain: Epigenetic Proaction Revisited

Evers

2020

Theoria

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Progress in neurosciencenotably, on the dynamic functions of neural networkshas deepened our understanding of decision-making, acquisition of character and temperament, and the development of moral dispositions. The evolution of our cerebral architecture is both genetic and epigenetic: the nervous system develops in continuous interaction with the immediate physical and socio-cultural environments. Each individual has a unique cerebral identity even in the relative absence of genetic distinction, and the development of this identity is strongly influenced by social and cultural environments leaving major traces in the connectivity of the brain. This interaction introduces important elements of variability and plasticity. Synaptic epigenetic theories of cultural and social imprinting on our brain architecture suggest the possibility that we can be "epigenetically proactive" and adapt our social structures, in both the short and the long term, to benefit and constructively interact with the ever-developing neuronal architecture of our brains. Epigenetic proaction can be described as a way to socially steer evolution by influencing the cultural imprints to be stored in our brains. The purpose of this article is to present, in a historical and ideological light, the idea that we may culturally shape the developing brain, and discuss some key risks and benefits of this endeavour. The article is a contribution to neuroethics.

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Shade gardens / by Oliver E. Allen and the editors of Time-Life Books.

Cited by 4 publications

References 0 publications

Identification of Clinically Relevant Molecular Subtypes in Colorectal Cancer: The Dawning of a New Era

Identification of Clinically Relevant Molecular Subtypes in Colorectal Cancer: The Dawning of a New Era

The Adoption of the Multidivisional Form of Organization: A Contingency Model*

The Culture‐Bound Brain: Epigenetic Proaction Revisited

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