Compared to traditional composite steel-concrete beams, where the concrete slab is supported by the top flange of a steel profile, in slim floor systems, the beam is integrated into the height of the concrete slab. These configurations are popular due to their cost-effectiveness and fire performance. However, fire design requires advanced calculation models, as Eurocodes do not provide a simplified method for the analysis of these types of beams when exposed to fire. The validation of the numerical models is an important issue for researchers, designers, software developers, and authorities. The European Standard for the fire design of composite steel and concrete structures, EN 1994-1-2, states that advanced calculation models must be validated against experimental test results. The paper presents the validation of a numerical model, for the thermal and mechanical analysis of slim floor beams, using SAFIR software. SAFIR is a special purpose computer program, based on the Finite Element Method, developed for the analysis of structures under elevated temperature conditions. The model is validated against an existing experimental fire test, available in the literature. The temperatures on the cross-section and the vertical beam displacements obtained numerically are reproducing very well the experimental results.