Shanxi Province Cervical Cancer Screening Study: A Cross-Sectional Comparative Trial of Multiple Techniques to Detect Cervical Neoplasia

Belinson, Jerome L.; Qiao, You‐Lin; Pretorius, Robert G.; Zhang, W. H.; Elson, Paul; Li, L.; Pan, Q J; Fischer, Christine; Lorincz, A.; Zahniser, David J.

doi:10.1006/gyno.2001.6554

Cited by 98 publications

(172 citation statements)

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“…In the present study, pathological findings following colposcopy served as the standard, and the predictive value of the Pap test, the TCT, and the combination test were compared. The results showed that the sensitivity of the combination test was 65.85%, which was markedly higher than that of Pap test (43.08%), but comparable to that of the TCT alone (80.00%) which is similar to the sensitivity of the TCT previously reported (Belinson et al, 2001). A study examining the use of only the TCT for screening reported that the TCT with ASCUS as positive had a sensitivity for CIN 2 of 94% and specificity of 78%, a sensitivity for CIN 3 of 98%, and for cancer of 100% (Belinson et al, 2002).…”

Section: Discussionsupporting

confidence: 79%

“…Screening a large, rural population must take into consideration the sensitivity and specificity of the testing, ease of administration, and costs involved (Belinson et al, 1999). Although there have been a number of studies evaluating different methods and screening programs for cervical cancer in China, no ideal one has been identified (Belinson et al, 1999;Belinson et al, 2001;Belinson, 2002;Pan et al, 2003;Li et l., 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The ThinPrep cytological test (TCT), a liquid-based method has been shown to have an increased sensitivity over that of the Pap test in screening for cervical cancer; however, it is more costly and requires specific equipment and specially trained personnel (Abulafa et al, Carns ey al., 2008). However, screening of very large numbers of individuals in a largely rural setting is associated with significant costs and logistical difficulties (Belinson et al, 1999;Belinson et al, 2001;Belinson, 2002;Pan et al, 2003;Li et al, 2009). Currently, the TCT has not been widely applied in China.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Pap Test in Combination with ThinPrep Cytological Test in Screening for Cervical Cancer

Chen

Shu²,

Chang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of Pap Test in Combination with ThinPrep Cytological Test in Screening for Cervical Cancer

Chen

Shu²,

Chang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The bias of HPV-based verification diminishes successively with increasing length of follow-up using conventional cytology and most of the women in the cohort were followed for more than two screening rounds (in Sweden the screening interval is 3 years). Also, detection of CIN2 þ is exceedingly rare when HPV-negative, cytology-negative women are referred to colposcopy suggesting that verification bias has not materially affected our estimates (Belinson et al, 2001).…”

Section: Discussionmentioning

confidence: 96%

HPV type-specific risks of high-grade CIN during 4 years of follow-up: A population-based prospective study

et al. 2007

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We followed a population-based cohort of 5696 women, 32 -38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2 þ development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and were responsible for 33.1, 18.3 and 7.7% of CIN2 þ cases, respectively. Women infected with HPV 18, 35, 39, 45, 51, 52, 56, 58, 59 and 66 had significantly lower risks of CIN2 þ than women infected with HPV 16. After adjustment for infection with other HPV types, HPV types 35, 45, 59 and 66 had no detectable association with CIN2 þ . In summary, the different HPV types found in cervical cancer show distinctly different CIN2 þ risks, with high risks being restricted to HPV 16 and its close relatives HPV 31 and HPV 33. Infection with 'high-risk' types of HPV is the major cause of cervical cancer, and the distribution of different HPV types in cancer tissue has been extensively analysed (Walboomers et al, 1999;Bosch et al, 2002;Munoz et al, 2003). Fifteen HPV types that infect the genital mucosa have been proposed as 'high-risk' HPV types as they have been found more often in cervical cancers than among healthy subjects . Data on the HPV type-specific risk of cervical neoplasia has hitherto mostly been based on cross-sectional case -control studies (Bosch et al, 1995;Clifford et al, 2003;Munoz et al, 2003). Case -control studies are sensitive to several biases, notably selection bias, differential sampling bias and other reverse causality biases. Absolute risks and population attributable proportions for each HPV type form the basis for decisions regarding which HPV types should be included in HPV screening tests as well as in vaccines and it is therefore important to estimate the type-specific risks using population-based prospective studies, a study design that minimises major sources of bias.Only two previous prospective studies have assessed the risk associated with several individual HPV types Berkhof et al, 2006), while several prospective studies have assessed certain clusters of HPV types (Koutsky et al, 1992;Liaw et al, 1999;Sherman et al, 2003;Szoke et al, 2003;Peto et al, 2004;Winer et al, 2005) or only investigated HPV types 16 and 18 (Khan et al, 2005).Therefore, we HPV-tested a population-based cohort of women and used a comprehensive registry-based follow-up to identify the risks for development of histopathologically verified high-grade cervical intraepithelial neoplasia (CIN2 þ ) associated with infections with 14 different so-called 'high-risk' HPV types. MATERIALS AND METHODS Cohort definitionA population-based multicentre study was started in Sweden in May 1997 with the main purpose to evaluate the effect of HPV testing in primary cervical cancer screening. Women aged between 32 and 38 years (mean age: 35.1 years) in five regions in Sweden (Gothenburg, Malmö, Stockholm, Umeå and Uppsala) who took part in organised cervical screening were invited to take part in the study. Followi...

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“…The published literature on HPV testing is based on cross-sectional assessments of the relation between positivity and lesions but provides reassuringly high negative predictive values. [13][14][15] However, no studies provide information on the long-term risk of women for HPV who have negative HPV results at their first screening. Such studies are needed to orient future policy decisions concerning screening intervals and the need for ancillary tests to improve prognostic performance.…”

mentioning

confidence: 99%

Innovations in understanding the biology of cervical cancer

Wolf

Ph.D.

Arbeit

et al. 2003

Cancer

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Shanxi Province Cervical Cancer Screening Study: A Cross-Sectional Comparative Trial of Multiple Techniques to Detect Cervical Neoplasia

Cited by 98 publications

References 0 publications

Efficacy of Pap Test in Combination with ThinPrep Cytological Test in Screening for Cervical Cancer

Efficacy of Pap Test in Combination with ThinPrep Cytological Test in Screening for Cervical Cancer

HPV type-specific risks of high-grade CIN during 4 years of follow-up: A population-based prospective study

Innovations in understanding the biology of cervical cancer

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