Shaoyao Gancao Decoction Ameliorates Paclitaxel-Induced Peripheral Neuropathy via Suppressing TRPV1 and TLR4 Signaling Expression in Rats

Chen, Yu; Lu, Ruohuang; Wang, Yang; Gan, Pingping

doi:10.2147/dddt.s357638

Cited by 6 publications

(1 citation statement)

References 54 publications

(54 reference statements)

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“…In addition, inhibition of the TLR4/p38 pathway decreased GFAP expression in the spinal dorsal horn tissues, suggesting that FMT alleviated the behavioral hypersensitivity in PIPN rats by blocking the TLR4/p38 pathway. 11,60 Therefore, we conclude that gut microbiota might play a significant role in suppressing the activation of the TLR4/p38 pathway and astrocytes in PIPN rats.…”

Section: Discussionmentioning

confidence: 68%

Fecal Microbiota Transplantation Alleviated Paclitaxel-Induced Peripheral Neuropathy by Interfering with Astrocytes and TLR4/p38MAPK Pathway in Rats

Shi,

Chen,

Zheng

et al. 2023

JPR

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Paclitaxel-induced peripheral neuropathy (PIPN) constitutes a refractory and progressive adverse consequence of paclitaxel treatment, causing pain and sensory anomalies in cancer survivors. Although the gut-brain axis is involved in multiple disorders including cancer, its impact on peripheral pain conditions remains elusive. Thus, we assessed the importance of gut microbiota and related mechanisms in PIPN. Methods: By implementing fecal microbiota transplantation (FMT) in a rat PIPN model (ie, rats treated with paclitaxel; hereafter as PIPN rats), we explored the effect of gut microbiota on PIPN rats using multiple methods, including different behavioral tests, 16S ribosomal DNA (rDNA) sequencing, and biochemical techniques. Results: Sequencing of 16S rDNA revealed that the abundance of genera Bacteroides and UCG-005 increased, while that of genera Turicibacter, Clostridium sensu stricto 1 and Corynebacterium decreased in the PIPN rats. However, when treated with FMT using fecal from normal rats, the mechanical allodynia and thermal hyperalgesia in PIPN rats were significantly alleviated. In addition, FMT treatment reduced the expression of toll-like receptor 4 (TLR4), phospho-p38 mitogen-activated protein kinase (p-p38MAPK), and the astrocytic marker glial fibrillary acidic protein in the colon and spinal dorsal horn. TAK242 (a TLR4 inhibitor) significantly alleviated the behavioral hypersensitivity of PIPN rats and inhibited the TLR4/p38MAPK pathway in astrocytes in these rats. Conclusion:The gut microbiota played a critical role in PIPN. Future therapies treating PIPN should consider microbe-based treatment as an option.

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Section: Discussionmentioning

confidence: 68%

Fecal Microbiota Transplantation Alleviated Paclitaxel-Induced Peripheral Neuropathy by Interfering with Astrocytes and TLR4/p38MAPK Pathway in Rats

Shi,

Chen,

Zheng

et al. 2023

JPR

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Traditional, Complementary, and Integrative Medicine and Cancer Care in the UAE

Kussmann

2024

Cancer Care in the United Arab Emirates

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Traditional, complementary, and integrative medicine (TCIM) in oncology is an emerging field of care comprising over 40 different licensed professionals with varying amounts of evidence supporting their respective professional treatments and regimens. This chapter presents summary information about the TCIM profession of naturopathic medicine and the subspecialty of naturopathic oncology, as well as the evidence supporting the use of naturopathic options with conventional care for cancer. Evidence supporting integrative treatments and natural health products for each type of conventional cancer treatment is presented. There is an opportunity in the UAE to collaborate and include all integrative oncology professionals in all phases of care for people with cancer.

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Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation

Ying,

Yue,

Yuwen

et al. 2025

Phytomedicine Plus

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Shaoyao Gancao Decoction Ameliorates Paclitaxel-Induced Peripheral Neuropathy via Suppressing TRPV1 and TLR4 Signaling Expression in Rats

Cited by 6 publications

References 54 publications

Fecal Microbiota Transplantation Alleviated Paclitaxel-Induced Peripheral Neuropathy by Interfering with Astrocytes and TLR4/p38MAPK Pathway in Rats

Fecal Microbiota Transplantation Alleviated Paclitaxel-Induced Peripheral Neuropathy by Interfering with Astrocytes and TLR4/p38MAPK Pathway in Rats

Traditional, Complementary, and Integrative Medicine and Cancer Care in the UAE

Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation

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