Shape and Size Effect on Photothermal Heat Elevation of Gold Nanoparticles: Absorption Coefficient Experimental Measurement of Spherical and Urchin-Shaped Gold Nanoparticles

Moustaoui, Hanane; Saber, Justine; Djeddi, Ines; Liu, Qiqian; Diallo, Amadou Thierno; Spadavecchia, Jolanda; Chapelle, Marc Lamy de la; Djaker, Nadia

doi:10.1021/acs.jpcc.9b03122

Cited by 65 publications

(57 citation statements)

References 56 publications

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“…GNPs can be developed in different morphologies such as nanospheres, nanorods, nanoshells, nanourchins, and more. Depending on the shapes and sizes, the surface plasmon resonance (SPR) can be over a wide spectrum from visible to NIR region 12 , 13 . For instance, GNSs have SPR in the visible region and GNRs have strong SPR in the NIR region.…”

Section: Introductionmentioning

confidence: 99%

Absorption cross section of gold nanoparticles based on NIR laser heating and thermodynamic calculations

Alrahili

Savchuk

McNear

et al. 2020

Sci Rep

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We present a method for measuring the optical absorption cross section ($$\sigma_{abs}$$ σ abs ) of gold nanoparticles (GNPs) based on optically heating the solution of GNPs with an 808 nm near-infrared (NIR) laser and measuring the temperature increase of the solution. We rely on the theoretical calculations based on the heat diffusion equations and experimental measurements based on the energy balance equations to measure the $$\sigma_{abs}$$ σ abs and the temperature distribution of single GNPs. Several morphologies, including gold nanospheres (GNSs), spherical gold nanoparticle conjugate (AuNPC), which are 20 nm GNSs surface-functionalized with an IR 808 dye, gold nanorods (GNRs), and gold nanourchins (GNUs), were studied. The study found that a single 20 nm GNS has the lowest $$\sigma_{abs}$$ σ abs and temperature distribution as compared to 100 nm GNUs. By increasing the size of GNSs from 20 to 30 nm, the magnitude of $$\sigma_{abs}$$ σ abs as well as temperature distribution increases by a factor of 5. The $$\sigma_{abs}$$ σ abs values of 20 and 30 nm GNSs calculated by Mie theory and the experimentally measured are in a good agreement. GNRs with equivalent radius ($$R_{eq}$$ R eq ) 9.16 nm show the second lowest $$\sigma_{abs}$$ σ abs . By increasing the $$R_{eq}$$ R eq by a factor of 2 to 19.2 nm, the measured $$\sigma_{abs}$$ σ abs and temperature distribution also increased by a factor of 2. We also estimated $$\sigma_{abs}$$ σ abs for GNUs with diameters at 80 and 100 nm, which also have higher $$\sigma_{abs}$$ σ abs values. This work confirms that we can use temperature to accurately measure the $$\sigma_{abs}$$ σ abs of a variety of GNPs in solution.

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Section: Introductionmentioning

confidence: 99%

Absorption cross section of gold nanoparticles based on NIR laser heating and thermodynamic calculations

Alrahili

Savchuk

McNear

et al. 2020

Sci Rep

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“…As reported before, at this scale of concentrations, each particle plays a role of an independent heat source and there is no gradient or coupling effects. [12,36] GNR ( Figure 3B,C) show a higher temperature elevation than GNU ( Figure 3A) at a same concentration especially close to the LSPR positions, where the photon-heat conversion is higher. [52,53] All the curves in Figure 3 were fitted with a linear model and show an increase of the slope depending on the wavelength.…”

Section: Gnrs Heating Measurements Under Near-ir Illuminationmentioning

confidence: 99%

“…From these last expressions, the absorption cross section (σ Abs ) can be determined using the equation [16,17,36]…”

Section: Gnrs Heating Measurements Under Near-ir Illuminationmentioning

confidence: 99%

“…[8][9][10][11] This physical process involves experimental method allowing the calculation of this parameter (σ abs ) from in situ measurement of the temperature elevation in water at different concentrations of gold nanoparticles. [36] In the present work, we have used the same methodology to calculate and compare σ abs values in the case of GNR and GNU as a function of the wavelength in the NIR region. For this purpose, different concentrations of GNU and GNR with different sizes were used to explore the temperature elevation in water by varying the excitation wavelength.…”

Section: Introductionmentioning

confidence: 99%

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Size, Shape, and Wavelength Effect on Photothermal Heat Elevation of Gold Nanoparticles: Absorption Coefficient Experimental Measurement

Diallo

Tlemçani

Khan

et al. 2020

Part & Part Syst Charact

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Complex‐shaped nanoparticles as gold nanourchins (GNU) and nanorods (GNR) are very suitable agents in the case of photothermal therapy due to their photon‐heat conversion ability in the red and near‐infrared region (NIR). The quantification in heat generation of complex shaped nanostructures is an important key to predict the therapeutic effect of these nanoparticles. For that, the determination of the nanoparticles absorption cross section (σAbs) responsible for the heat generation is one of the important steps before any application. Although it is obvious to determine σAbs for spheres via Mie's theory, in the case of complex structures like GNU or GNR, this parameter is difficult to model. In this work, a new methodology is used to determine experimentally σAbs for both GNU and GNR. Experimental measurements of the photothermal properties of 100 nm size GNU and two different sizes of GNRs are studied regarding different parameters such as concentration, laser excitation wavelength, and exposure time. By using the heat transfer theory, the temperature elevation in the nanoparticles solutions is converted to temperature elevation at the nanoparticles surface and σAbs values are then calculated for both GNU and GNR in the NIR spectral region.

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“…They have another advantage of tunable NIR absorbance due to their localized surface plasmon resonance (LSPR) ( Ding et al, 2014 ; Eyvazzadeh et al, 2017 ), which means photothermal conversion capability of AuNPs can be controlled by adjusting their shapes and sizes ( Hwang et al, 2014 ). Benefited from these features, optimal cancer therapeutic effect can be achieved by choosing the appropriate AuNPs ( Mackey et al, 2014 ; Moustaoui et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Folic Acid–Functionalized Composite Scaffolds of Gelatin and Gold Nanoparticles for Photothermal Ablation of Breast Cancer Cells

Chen

Wang

Sutrisno

et al. 2020

Front. Bioeng. Biotechnol.

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Photothermal therapy (PTT) has been developed as a useful therapeutic method for cancer treatment. Localization of PTT agents in cancer sites and targeting capacity are required to further increase therapeutic efficacy. In this study, gold nanoparticles (AuNPs) and gelatin were functionalized with folic acid (FA) and hybridized to prepare FA-functionalized gelatin–AuNPs composite scaffolds. AuNPs with rod and star shapes of three sizes (40, 70, and 110 nm) were used for the hybridization to investigate the influence of AuNPs shape and size. The composite scaffolds showed porous structures with good interconnectivity. Modification with FA increased capture capacity of the composite scaffolds. Hybridization with AuNPs rendered the composite scaffold a good photothermal conversion property under near-infrared (NIR) laser irradiation. Temperature change during laser irradiation increased with the laser power intensity and irradiation time. The shape and size of AuNPs also affected their photothermal conversion property. The composite scaffold of gold nanorods 70 (FA-G/R70) had the highest photothermal conversion capacity. Breast cancer cells cultured in the FA-G/R70 composite scaffold were killed under NIR laser irradiation. Mouse subcutaneous implantation further demonstrated the excellent photothermal ablation capability of FA-G/R70 composite scaffold to breast cancer cells. The FA-functionalized composite scaffolds were demonstrated a high potential for local PPT of breast cancer.

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Shape and Size Effect on Photothermal Heat Elevation of Gold Nanoparticles: Absorption Coefficient Experimental Measurement of Spherical and Urchin-Shaped Gold Nanoparticles

Cited by 65 publications

References 56 publications

Absorption cross section of gold nanoparticles based on NIR laser heating and thermodynamic calculations

Absorption cross section of gold nanoparticles based on NIR laser heating and thermodynamic calculations

Size, Shape, and Wavelength Effect on Photothermal Heat Elevation of Gold Nanoparticles: Absorption Coefficient Experimental Measurement

Folic Acid–Functionalized Composite Scaffolds of Gelatin and Gold Nanoparticles for Photothermal Ablation of Breast Cancer Cells

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