Shape-dependent significant physical mutilation and antibacterial mechanisms of gold nanoparticles against foodborne bacterial pathogens (Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) at lower concentrations

Hameed, Saima; Wang, Yingli; Zhao, Lin; Xie, Lijuan

doi:10.1016/j.msec.2019.110338

Cited by 54 publications

(27 citation statements)

References 40 publications

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“…This effect was caused by the CTAB and silver nitrate (AgNO 3 ) solutions, which were used up during the synthesis. The generated AgBr–ions block the growth of the AuNPs in the direction 26 , 27 . Therefore, the nanoparticles were expected to grow parallel to the 16 planes forming elongated structures as for the AuR NPs in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…However, it was noted that extending the synthesis time caused the ends of the edges to start growing in the direction, creating the AuP NPs (Fig. 1 B1,B2), which was likely due to depletion of the CTAB and the AgNO 3 particles in the solution at the end of the synthesis 26 . In Fig.…”

Section: Resultsmentioning

confidence: 99%

“…These pores were formed as a result of the high temperature synthesis. The condition under high temperature caused increase of the gold precursor reduction speed and unblocking of the nanoparticles growth in the direction by destabilization of CTAB molecules 26 . Moreover, STEM images of AuSph (CTAB) NPs, Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The antimicrobial effects of metal nanoparticles are a result of their morphology and surface charge, which are the critical factors that affect the interaction of NPs with microorganisms 40 – 42 . AuNPs have therefore been synthesized in a broad spectrum of sizes and shapes, including spherical nanoparticles 22 , 43 , nanorods 22 , nanocubes 26 , nanostars, and nanoflowers 25 . In our study, through the addition of CTAB—a cationic agent commonly used in the synthesis of varied-shape nanomaterials 44 —and by varying the synthesis time, we developed a series of varied-shaped gold nanoparticles in shape of nanorods (AuR NPs), nanopeanuts (AuP NPs) and nanostars (AuS NPs), as well as spherical-like porous nanoparticles [AuSph (70C) NPs].…”

Section: Discussionmentioning

confidence: 99%

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Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices

Piktel

Suprewicz

Depciuch

et al. 2021

Sci Rep

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Medical device-associated infections are a serious medical threat, particularly for patients with impaired mobility and/or advanced age. Despite a variety of antimicrobial coatings for medical devices being explored to date, only a limited number have been introduced for clinical use. Research into new bactericidal agents with the ability to eradicate pathogens, limit biofilm formation, and exhibit satisfactory biocompatibility, is therefore necessary and urgent. In this study, a series of varied-morphology gold nanoparticles in shapes of rods, peanuts, stars and spherical-like, porous ones with potent antibacterial activity were synthesized and thoroughly tested against spectrum of Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus clinical strains, as well as spectrum of uropathogenic Escherichia coli isolates. The optimization of gold nanoparticles synthesis allowed to develop nanomaterials, which are proved to be significantly more potent against tested microbes compared with the gold nanoformulations reported to date. Notably, their antimicrobial spectrum includes strains with different drug resistance mechanisms. Facile and cost-efficient synthesis of gold nanoparticles, remarkable bactericidal efficiency at nanogram doses, and low toxicity, underline their potential for development as a new coatings, as indicated by the example of urological catheters. The presented research fills a gap in microbial studies of non-spherical gold nanoparticles for the development of antimicrobial coatings targeting multidrug-resistant pathogens responsible for device-associated nosocomial infections.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices

Piktel

Suprewicz

Depciuch

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The gold peanuts have a prevailing bactericidal effect over other shapes. Hameed et al demonstrated that gold nanocubes showed the most significant bactericidal properties, even at lower concentrations, against E. coli , P. aeruginosa , and S. aureus , followed by Au NSps (nanospheres) and Au NSts (nanostars) [ 158 ].…”

Section: Biological Effect and Applicationmentioning

confidence: 99%

Nanomaterial Shape Influence on Cell Behavior

Kladko

Falchevskaya

Serov

et al. 2021

IJMS

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Nanomaterials are proven to affect the biological activity of mammalian and microbial cells profoundly. Despite this fact, only surface chemistry, charge, and area are often linked to these phenomena. Moreover, most attention in this field is directed exclusively at nanomaterial cytotoxicity. At the same time, there is a large body of studies showing the influence of nanomaterials on cellular metabolism, proliferation, differentiation, reprogramming, gene transfer, and many other processes. Furthermore, it has been revealed that in all these cases, the shape of the nanomaterial plays a crucial role. In this paper, the mechanisms of nanomaterials shape control, approaches toward its synthesis, and the influence of nanomaterial shape on various biological activities of mammalian and microbial cells, such as proliferation, differentiation, and metabolism, as well as the prospects of this emerging field, are reviewed.

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Therapeutic strategies for drug‐resistant Pseudomonas aeruginosa: Metal and metal oxide nanoparticles

Zhan,

Hu,

et al. 2024

J Biomedical Materials Res

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Pseudomonas aeruginosa (PA) is a widely prevalent opportunistic pathogen. Multiple resistant strains of PA have emerged from excessive or inappropriate use of antibiotics, making their eradication increasingly difficult. Therefore, the search for highly efficient and secure novel antimicrobial agents is crucial. According to reports, there is an increasing exploration of nanometals for antibacterial purposes. The antibacterial mechanisms involving the nanomaterials themselves, the release of ions, and the induced oxidative stress causing leakage and damage to biomolecules are widely accepted. Additionally, the study of the cytotoxicity of metal nanoparticles is crucial for their antibacterial applications. This article summarizes the types of metal nanomaterials and metal oxide nanomaterials that can be used against PA, their respective unique antibacterial mechanisms, cytotoxicity, and efforts made to improve antibacterial performance and reduce toxicity, including combination therapy with other materials and antibiotics, as well as green synthesis approaches.

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Shape-dependent significant physical mutilation and antibacterial mechanisms of gold nanoparticles against foodborne bacterial pathogens (Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) at lower concentrations

Cited by 54 publications

References 40 publications

Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices

Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices

Nanomaterial Shape Influence on Cell Behavior

Therapeutic strategies for drug‐resistant Pseudomonas aeruginosa: Metal and metal oxide nanoparticles

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