Shape design of an artificial pump-lung using high-resolution hemodynamic simulation with high-performance computing

Abstract

Accurate and fast prediction of the hemodynamics of the artificial pump-lung is critical in the design process. In this study, a comprehensive computational framework, including a sliding mesh method, a coupled free flow and porous media flow model, a hemolysis prediction method, a k-ω SST (shear stress transport) turbulence model, and solution algorithms, is introduced to accurately predict the velocity field, pressure heads and hemolysis. The framework is used to do the shape design of an artificial pump-lung on a supercomputer. High-resolution hemodynamics simulation results are obtained and analyzed, and the parallel performance of the algorithm is studied. The numerical results indicate that the proposed framework is capable of accurately predicting the velocity field, pressure heads, and hemolysis, and the performance of the designed artificial pump-lung meets the biocompatibility requirements. Additionally, the parallel performance results demonstrate the potential of the framework to efficiently perform the design of artificial pump-lungs using a large number of processors.

Scaled-up Microfluidic Lung Assist Device for Artificial Placenta Application with High Gas Exchange Capacity

“…Additionally, this configuration leads to nonuniform blood flow and high shear regions, requiring high levels of heparinization, which is detrimental to premature neonates. 7,12,13 To overcome these limitations, microfluidic blood oxygenator devices have been developed to provide a more streamlined and uniform flow of blood adjacent to a gas exchange membrane with optimal pressure drop, low priming volume, and reasonable gas exchange capability. 12,14,15 The artificial placenta concept on the other hand mimics the biological circulation of the blood in the fetus when inside the mother's womb and can be used to oxygenate fetal blood and eliminate carbon dioxide.…”

“…This reduces pressure drop but increases priming volume, making them unsuitable for supporting neonates without blood transfusions. Additionally, this configuration leads to nonuniform blood flow and high shear regions, requiring high levels of heparinization, which is detrimental to premature neonates. ,, To overcome these limitations, microfluidic blood oxygenator devices have been developed to provide a more streamlined and uniform flow of blood adjacent to a gas exchange membrane with optimal pressure drop, low priming volume, and reasonable gas exchange capability. ,, …”

Design Optimization of a Phototherapy Extracorporeal Membrane Oxygenator for Treating Carbon Monoxide Poisoning

“…However, the traditional parameter and shape optimization of an ECMO device can be costly and time consuming since numerous physical experiments must be performed. Alternatively, computational fluid dynamics (CFD) can provide a fast, flexible, and accurate model [ 14 ]. CFD has been used to model blood flow in pumps, gas flow in gas exchange hollow fibers, and hemodynamic performance with good agreement with ex vivo and in vitro experiments [ 14 ].…”

“…Alternatively, computational fluid dynamics (CFD) can provide a fast, flexible, and accurate model [ 14 ]. CFD has been used to model blood flow in pumps, gas flow in gas exchange hollow fibers, and hemodynamic performance with good agreement with ex vivo and in vitro experiments [ 14 ]. Han et al analyzed and compared three leading centrifugal blood pumps to identify the risk of hemolysis when using CFD and experiments [ 15 ].…”