Shape Matters: Crystal Morphology and Surface Topography Alter Bioactivity of Bioceramics in Simulated Body Fluid

Abstract

For bioactive biomaterials such as bioceramics and bioglass, it is generally accepted that, apart from acting as heterogeneous nucleators, it is their solubility and the resulting release of relevant ions such as calcium or basic anions which mainly governs the biomaterial's bioactivity. This contribution reveals that this bioactivity, as assessed by simulated body fluid (SBF), can also be considerably modified by the bioceramic's morphology, i.e., bioactivity is also governed by microstructure and surface morphology. When crystals are forced to adopt out‐of‐equilibrium crystal habit, this simple change in morphology converts an essentially bioinert material, here calcite, into a bioceramic which shows bioactivity in SBF. On larger length scales, already simple morphological changes, such as scratches, can have inverse effects. Limited mass transport into grooves and pits on a bioceramic surface can lead to local ion depletion which, in turn, causes reduced bioactivity of bioceramics which, otherwise, show distinct bioactivity in SBF. This contribution emblematically illustrates the unforeseen importance of even minor morphology changes on different length scales when assessing and designing a biomaterial's bioactivity through SBF assays.

Biomimetic Research for Applications Addressing Technical Environmental Protection

“…Such materials could be used for bone implants, for example, and in the long term, could represent a sustainable alternative to the energy-intensive ceramic processes. In this project, the newly developed biomimetic synthesis approach, a layer-by-layer process, is particularly suited to generate analogous crystallographic gradients and bioactive coatings for biomedical implants in an energy efficient synthesis [ 33 , 34 , 35 ].…”

Sustained Calcium(II)-Release to Impart Bioactivity in Hybrid Glass Scaffolds for Bone Tissue Engineering

“…We observed a formation of round shaped mineral with cauliflower morphology and partially needle-like structures, that can be attributed to the apatite-like mineral [ 15 , 68 , 69 , 70 ]. Generally, material bioactivity is related to its elemental composition (Si/Ca/P–ratio), textural properties, such as surface morphology, pore structure, pore size and pore volume [ 3 , 68 , 71 , 72 , 73 , 74 ]. The bioactivity of 0C10P scaffolds observed at day 14 may be therefore attributed to the changed surface textural properties and increased porosity, caused by the leaching of TEP during the template dissolution.…”