Shape memory materials and 4D printing in pharmaceutics

Melocchi, Alice; Uboldi, Marco; Cerea, Matteo; Foppoli, Anastasia; Moutaharrik, Saliha; Palugan, Luca; Gazzaniga, A.

doi:10.1016/j.addr.2021.03.013

Cited by 83 publications

(47 citation statements)

References 156 publications

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“…Coating implants for expedited healing and recovery is an area with great therapeutic potential, however, refinements and standardization will be required prior to clinical translation. Developments utilizing shape memory materials [e.g., smart or intelligent materials ( Huang et al, 2019 ; Zhao et al, 2019 )] and dynamic response composites which can adapt to external stimuli, could offer significant advantages in EV-coated implant/scaffold systems for wound treatment ( Melocchi et al, 2021 ). Further improvements to EV-based therapeutic delivery will be made with additional molecular characterization of EV-tissue tropism, biodistribution, and delivery mechanism designs to ensure the specificity of therapeutic delivery for specific cell types.…”

Section: Challenges To Further Development Of Ev Therapiesmentioning

confidence: 99%

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities

Claridge

Lozano

Poh

et al. 2021

Front. Cell Dev. Biol.

111

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Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their endogenous characteristics, however, further bioengineering refinement is required to address clinical and commercial limitations. Clinical applications of EV-based therapeutics are being trialed in immunomodulation, tissue regeneration and recovery, and as delivery vectors for combination therapies. Native/biological EVs possess diverse endogenous properties that offer stability and facilitate crossing of biological barriers for delivery of molecular cargo to cells, acting as a form of intercellular communication to regulate function and phenotype. Moreover, EVs are important components of paracrine signaling in stem/progenitor cell-based therapies, are employed as standalone therapies, and can be used as a drug delivery system. Despite remarkable utility of native/biological EVs, they can be improved using bio/engineering approaches to further therapeutic potential. EVs can be engineered to harbor specific pharmaceutical content, enhance their stability, and modify surface epitopes for improved tropism and targeting to cells and tissues in vivo. Limitations currently challenging the full realization of their therapeutic utility include scalability and standardization of generation, molecular characterization for design and regulation, therapeutic potency assessment, and targeted delivery. The fields’ utilization of advanced technologies (imaging, quantitative analyses, multi-omics, labeling/live-cell reporters), and utility of biocompatible natural sources for producing EVs (plants, bacteria, milk) will play an important role in overcoming these limitations. Advancements in EV engineering methodologies and design will facilitate the development of EV-based therapeutics, revolutionizing the current pharmaceutical landscape.

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Section: Challenges To Further Development Of Ev Therapiesmentioning

confidence: 99%

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities

Claridge

Lozano

Poh

et al. 2021

Front. Cell Dev. Biol.

111

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“…Shape memory polymers (SMPs) are able to undergo major shape modifications under the application of a range of triggering stimuli , such as changes in temperature, light, magnetic field and electrical currents, which could even be applied remotely ( Lendlein and Langer, 2002 ; Melocchi et al, 2021c ; Shin et al, 2017 ; Zhang et al, 2019 ). The rising interest towards these polymers could be considered a consequence of the spread of shape memory alloys (SMAs), which dates back to the end of the 90s.…”

Section: Strategies To Improve the Pharmacological Therapy Of Urinary Bladder Diseasesmentioning

confidence: 99%

Intravesical drug delivery approaches for improved therapy of urinary bladder diseases

Palugan

Cerea

Cirilli

et al. 2021

International Journal of Pharmaceutics: X

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Diseases of the urinary bladder have high incidence rates and burden healthcare costs. Their pharmacological treatment involves systemic and local drug administration. The latter is generally accomplished through instillation of liquid formulations and requires repeated or long-term catheterization that is associated with discomfort, inflammation and bacterial infections. Consequently, compliance issues and dropouts are frequently reported. Moreover, instilled drugs are progressively diluted as the urine volume increases and rapidly excreted. When penetration of drugs into the bladder wall is needed, the poor permeability of the urothelium has also to be accounted for. Therefore, much research effort is spent to overcome these hurdles, thereby improving the efficacy of available therapies. Particularly, indwelling delivery systems suited for i) insertion into the bladder through the urethra, ii) intra-organ retention and prolonged release for the desired time lapse, iii) final elimination, either spontaneous or by manual removal, have been proposed to reduce the number of catheterization procedures and reach higher drug levels at the target site. Vesical retention of such devices is allowed by the relevant expansion that can either be triggered from the outside or achieved exploiting elastic and purposely 4D printed shape memory materials. In this article, the main rationales and strategies for improved intravesical delivery are reviewed.

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“…[ 4–8 ] After the programmable deformation, SMPs could stabilize the temporary shape, and then spontaneously recover to the original shape upon the external stimuli, such as heat, [ 9 ] light, [ 10 ] electricity, [ 11 ] magnetism, [ 12 ] and solvent. [ 13 ] These unique programmable deformation manipulations impart SMPs with diverse applications, including electrical devices, smart actuators, health monitoring, and aerospace structures. [ 14–18 ]…”

Section: Introductionmentioning

confidence: 99%

Boron nitride enhanced shape memory poly(aryl ether ketone) actuators with rapid self‐deformation and staged responsive behaviors

Yang

Leng

2022

Polymer Composites

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In this paper, boron nitride (BN) sheets, as two‐dimensional thermal conductive fillers, were integrated into shape memory poly(aryl ether ketone) (PAEK) matrix to improve the response speed of actuators. The thermal conductivity of composites was found to be positively correlated with the content of BN sheets. Significantly, a highest in‐plane thermal conductivity of 2.66 W m−1 K−1 was obtained, which resulted in the increase of the recovery speed of the PAEK/BN actuators from 18 to 6 s. Besides, the integration of BN sheets improved the shape memory effect of PAEK matrix, including the higher shape recovery ratio (up to 99.9%) and fixity ratio (over 97%). In addition, through the assembling of four components with designed BN contents, we achieved the interesting staged shape recovery behaviors for PAEK/BN composite actuators, which enabled programmable and smart manipulations. These fabricated PAEK/BN composite actuators with rapid response and staged deformation behaviors possessed the wide utilization potential in smart devices.

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Shape memory materials and 4D printing in pharmaceutics

Cited by 83 publications

References 156 publications

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities

Intravesical drug delivery approaches for improved therapy of urinary bladder diseases

Boron nitride enhanced shape memory poly(aryl ether ketone) actuators with rapid self‐deformation and staged responsive behaviors

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