Shape Memory Polyester Scaffold Promotes Bone Defect Repair through Enhanced Osteogenic Ability and Mechanical Stability

Du, Rui; Zhao, Bin; Luo, Kun; Wang, Man-Xi; Yuan, Quan; Yu, Lei-Xiao; Yang, Ke-Ke; Wang, Yu-Zhong

doi:10.1021/acsami.3c06902

Cited by 9 publications

(1 citation statement)

References 57 publications

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“…Large bone defects resulting from trauma, degenerative diseases, tumors, etc. have long been a vital clinical threat to human health. , Despite their widespread use, autologous and allogeneic bone grafts suffer from drawbacks, such as sacrificial bone donor sites, insufficient supply, and other surgical complications. − Three-dimensional (3D) printing, also known as additive manufacturing, is an innovative technique for boosting the development of bone tissue engineering, − because it can meet the clinical needs for personalized design and spatial porous constructs. , Among the available material choices, biodegradable polymers are identified as a preferred candidate due to their excellent biocompatibility, suitable mechanical properties, and good processability. , Numerous clinically approved biodegradable polymers, such as polycaprolactone (PCL), poly(lactic acid) (PLA), and poly(lactides- co -glycolides) (PLGA), etc., have been employed as the matrices to produce 3D-printed scaffolds. ,− Unfortunately, the bioinert nature of these biodegradable polymers results in insufficient biofunctions, hindering cellular activities and bone regeneration. , Thus, endowing 3D-printed scaffolds with osteoconductivity and osteogenesis is highly required to ensure their orthopedic applications.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Mineralized 3D-Printed Polycaprolactone Scaffold Induced by Self-Adaptive Nanotopology to Accelerate Bone Regeneration

Shen,

Xing,

Shang

et al. 2024

ACS Appl. Mater. Interfaces

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Three-dimensional (3D)-printed biodegradable polymer scaffolds are at the forefront of personalized constructs for bone tissue engineering. However, it remains challenging to create a biological microenvironment for bone growth. Herein, we developed a novel yet feasible approach to facilitate biomimetic mineralization via self-adaptive nanotopography, which overcomes difficulties in the surface biofunctionalization of 3D-printed polycaprolactone (PCL) scaffolds. The building blocks of self-adaptive nanotopography were PCL lamellae that formed on the 3D-printed PCL scaffold via surface-directed epitaxial crystallization and acted as a linker to nucleate and generate hydroxyapatite crystals. Accordingly, a uniform and robust mineralized layer was immobilized throughout the scaffolds, which strongly bound to the strands and had no effect on the mechanical properties of the scaffolds. In vitro cell culture experiments revealed that the resulting scaffold was biocompatible and enhanced the proliferation and osteogenic differentiation of mouse embryolous osteoblast cells. Furthermore, we demonstrated that the resulting scaffold showed a strong capability to accelerate in vivo bone regeneration using a rabbit bone defect model. This study provides valuable opportunities to enhance the application of 3D-printed scaffolds in bone repair, paving the way for translation to other orthopedic implants.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Mineralized 3D-Printed Polycaprolactone Scaffold Induced by Self-Adaptive Nanotopology to Accelerate Bone Regeneration

Shen,

Xing,

Shang

et al. 2024

ACS Appl. Mater. Interfaces

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Current status and challenges of shape memory scaffolds in biomedical applications

Wu,

Yang,

et al. 2024

MedComm – Biomaterials and Applications

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The rapid evolution of clinical medicine, materials science, and regenerative medicine has rendered traditional implantable scaffolds inadequate for addressing the complex therapeutic demands of various diseases. Currently, implantable scaffolds in clinical practice are mainly made of metal, with the disadvantages of high stiffness, poor toughness, and low deformation. This paper offers a thorough review of shape memory scaffolds (SMSs), emphasizing their distinctive self‐recovery and adaptive functionalities that enhance compatibility with injured tissues, surpassing the capabilities of conventional metallic biomaterials. It delves into the limitations of current clinical scaffolds and the requisite performance metrics for effective implants and outlines the essential materials and fabrication methods for SMSs. Moreover, we enumerate the biomedical applications of SMMs with different response types, including thermology‐responsive, water‐responsive, and light‐responsive. The discussion extends to the burgeoning applications of SMSs in biomedical engineering, including their utility in bone tissue engineering, cardiovascular stenting, tubular structures, and cardiac patches, which underscore their potential in minimally invasive procedures and dynamic tissue interactions. This review concludes with an analysis of current challenges and prospects, providing valuable insights for developing and applying SMSs in the biomedical sector.

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4D fabrication of shape-changing systems for tissue engineering: state of the art and perspectives

Bonetti,

Scalet

2024

Prog Addit Manuf

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In recent years, four-dimensional (4D) fabrication has emerged as a powerful technology capable of revolutionizing the field of tissue engineering. This technology represents a shift in perspective from traditional tissue engineering approaches, which generally rely on static—or passive—structures (e.g., scaffolds, constructs) unable of adapting to changes in biological environments. In contrast, 4D fabrication offers the unprecedented possibility of fabricating complex designs with spatiotemporal control over structure and function in response to environment stimuli, thus mimicking biological processes. In this review, an overview of the state of the art of 4D fabrication technology for the obtainment of cellularized constructs is presented, with a focus on shape-changing soft materials. First, the approaches to obtain cellularized constructs are introduced, also describing conventional and non-conventional fabrication techniques with their relative advantages and limitations. Next, the main families of shape-changing soft materials, namely shape-memory polymers and shape-memory hydrogels are discussed and their use in 4D fabrication in the field of tissue engineering is described. Ultimately, current challenges and proposed solutions are outlined, and valuable insights into future research directions of 4D fabrication for tissue engineering are provided to disclose its full potential.

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Shape Memory Polyester Scaffold Promotes Bone Defect Repair through Enhanced Osteogenic Ability and Mechanical Stability

Cited by 9 publications

References 57 publications

Biomimetic Mineralized 3D-Printed Polycaprolactone Scaffold Induced by Self-Adaptive Nanotopology to Accelerate Bone Regeneration

Biomimetic Mineralized 3D-Printed Polycaprolactone Scaffold Induced by Self-Adaptive Nanotopology to Accelerate Bone Regeneration

Current status and challenges of shape memory scaffolds in biomedical applications

4D fabrication of shape-changing systems for tissue engineering: state of the art and perspectives

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