Shape Memory Polyurethane Biocomposites Based on Toughened Polycaprolactone Promoted by Nano-Chitosan

Gupta, Arvind; Kim, Beom Soo

doi:10.3390/nano9020225

Cited by 35 publications

(35 citation statements)

References 44 publications

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“…Our group has demonstrated the development of PCL based polyurethane composite with chitosan [106]. Chitosan has an advantage of antibacterial property along with the induction of bone formation and wound healing ability which is shadowed by the limitation of its processing temperature.…”

Section: Author's Perspective On the Shape Memory Polyurethane Composmentioning

confidence: 99%

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Shape Memory Polyurethane and its Composites for Various Applications

2019

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The inherent capability to deform and reform in a predefined environment is a unique property existing in shape memory polyurethane. The intrinsic shape memory ability of the polyurethane is due to the presence of macro domains of soft and hard segments in its bulk, which make this material a potential candidate for several applications. This review is focused on manifesting the applicability of shape memory polyurethane and its composites/blends in various domains, especially to human health such as shielding of electromagnetic interference, medical bandage development, bone tissue engineering, self-healing, implants development, etc. A coherent literature review highlighting the prospects of shape memory polyurethane in versatile applications has been presented.

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Section: Author's Perspective On the Shape Memory Polyurethane Composmentioning

confidence: 99%

“…2019, 9, x FOR PEER REVIEW 24 of 29 Figure 18. Demonstration of the shape memory ability of PCL based polyurethane chitosan composite [106].…”

Section: Author's Perspective On the Shape Memory Polyurethane Composmentioning

confidence: 99%

Shape Memory Polyurethane and its Composites for Various Applications

2019

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“…There is indeed a particular interest in hydrogels, such as those made of co-polymers like the InGel® from Innocore, based on PCLA-PEG-PCLA tri-block copolymers with aliphatic end groups that are injectable and can be thermos-sensitive. Shape memory materials should also take an important place in the field of ocular delivery allowing to enroll in the vitreous cavity an enhanced length the material, increasing its loading capacity and release duration [64,65] . Other materials can be used, such as polyethyleneimine (PEI), particularly adapted to formulate nucleic acids such as antisense oligonucleotides or siRNA [66][67][68].…”

Section: Biodegradable Polymersmentioning

confidence: 99%

Recent advances in slow and sustained drug release for retina drug delivery

Béhar-Cohen

2019

Expert Opinion on Drug Delivery

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Highlights: • Drug delivery remains a major challenge in the treatment of retinal diseases • Degradable and non-degradable implants for the sustained and local release of glucocorticoids have been approved • Bolus of proteins neutralizing VEGF family members allow the maintenance of clinical benefit for 1 to 3 months • New reservoirs and polymeric dispersed systems are in development for intravitreous slow release of drugs and proteins • Few drug delivery systems cross the clinical stage due to insufficient multidisciplinary development • Fundamental work is still required to build guidelines for toxicity and models for ocular pharmacokinetic studies.

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“…Hence the industry has shifted to more eco-friendly renewable sources and the alternatives produced are the composites from PU and natural sources. Thus, PU biocomposites' main purpose is to decrease the environmental impact of non-organic engineered and petroleum-based fillers 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of diatomite and hydroxyapatite reinforced porous polyurethane foam biocomposites

Mustafov

Sen

Seydibeyoğlu

2020

Sci Rep

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Porous three-dimensional (3D) polyurethane-based biocomposites were produced utilizing diatomite and hydroxyapatite as fillers. Diatomite and Hydroxyapatite (HA) were utilized to reinforce the morphological, chemical, mechanical, and thermal properties of polyurethane foam (PUF). Diatomite and Hydroxyapatite were added into polyurethane at variable percentages 0, 1, 2, and 5. The mechanical properties of PUF were analyzed by the compression test. According to the compression test results, the compressive strength of the polyurethane foam is highest in the reinforced foam at 1% by weight hydroxyapatite compared to other reinforced PUFs. Scanning electron microscopy (SEM) images presented structural differences on foam by adding fillers. Functional groups of PUF were defined by Fourier Transform Infrared Spectroscopy (FTIR) and the thermal behavior of PUF was studied with Thermogravimetric Analysis (TGA). The obtained results revealed that PUF/HA biocomposites indicated higher thermal degradation than PUF/Diatomite biocomposites. The bone can be regarded as a composite substance composed of inorganic minerals mostly formed through hydroxyapatite (HA), which reinforces the bone structure and supplies mechanical strength and moreover an organic matrix consisting of type I collagen. Bone is good at self-regeneration, but the natural healing mechanism is difficult when significant bone loss, so medical implants are generally utilized to overcome the defect of bone. The temporary 3D scaffold, according to the bone tissue engineering approach, plays a significant role in controlling osteoblast functions as well as a fundamental role in guiding the new formation of bone into preferred forms 1. Scaffolds for bone regeneration serve primarily as substrates for binding and proliferation of osteogenic cells. Thus, like bone grafts, three-dimensional biodegradable materials with a porous structure were of big interest not only for their structural and composition similarities to the natural bone but also for their original functional properties, like greater surface area, and high mechanical strength 2. The most studied synthetic biodegradable polymers studied for bone tissue engineering include polylactic acid (PLA), polycaprolactones (PCL), polyglycolide (PGA), and polylactic-co-glycolic acid (PLGA) 3,4. However, when artificial biodegradable polymers are used, the right equilibrium among the rate of tissue regeneration and in vivo degradation is hard to accomplish. For this reason, other polymers, especially polyurethanes, can be utilized to produce scaffolds for the regeneration of bone tissue. The use of polyurethane for scaffolding is probable to achieve a much wider range of morphological and mechanical characteristics compared to mostly used biodegradable polymers 5. Polyurethanes (PU) are classically produced by polyaddition reactions of isocyanates with polyols (polyalcohols). Based on the formulation, a wide property spectrum from elastomer to rigid foams are readily designed and synthesized 6-8. Currently, they are...

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Shape Memory Polyurethane Biocomposites Based on Toughened Polycaprolactone Promoted by Nano-Chitosan

Cited by 35 publications

References 44 publications

Shape Memory Polyurethane and its Composites for Various Applications

Shape Memory Polyurethane and its Composites for Various Applications

Recent advances in slow and sustained drug release for retina drug delivery

Preparation and characterization of diatomite and hydroxyapatite reinforced porous polyurethane foam biocomposites

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