After years of development, holography has become an essential tool of modern optics for many applications. Among them, holographic encryption and dynamic display are the two most typical applications. So far, however, only 2D targets or 2D images of 3D targets can be encrypted with holographic technology. The 3D multiplexing holographic technology of 3D multi‐targets has not yet been realized and holographic encryption of 3D multi‐targets is still a blank. Here, the conception of 3D orbital angular momentum (OAM) multiplexing holography is proposed, and holographic encryption of 3D multi‐targets is realized for the first time. This breaks the restriction that only 2D images can be encrypted in traditional holographic encryption. Furthermore, the results also show that the 3D OAM holography can be used in the dynamic display for 3D multi‐targets. In the experiment, the metasurface is used for taking its high‐resolution advantage in light field manipulation, and verify the feasibility of 3D OAM multiplexing holographic technology, holographic encryption of 3D multi‐targets, and holographic dynamic display of 3D targets. The work creates a precedent for the 3D multiplexing holography, encryption, and dynamic display technology of 3D multi‐targets, which brings real 3D life closer to humankind.