Shaping smell: chloride currents dictate the kinetics of olfactory transduction

Fyke, Zach; Belonio, Kai Clane; Zak, Joseph D.

doi:10.1113/jp287393

The Journal of Physiology

2024

DOI: 10.1113/jp287393

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Shaping smell: chloride currents dictate the kinetics of olfactory transduction

Zach Fyke,

Kai Clane Belonio,

Joseph D. Zak

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2024

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Amplification of olfactory transduction currents implements sparse stimulus encoding

Belonio,

Haile,

Fyke

et al. 2024

Preprint

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Sensory systems must perform the dual and opposing tasks of being sensitive to weak stimuli while also maintaining information content in dense and variable sensory landscapes. This occurs in the olfactory system, where OSNs are highly sensitive to low concentrations of odors and maintain discriminability in complex odor environments. How olfactory sensory neurons (OSNs) maintain both sensitivity and sparsity is not well understood. Here, we investigated whether the calcium-activated chloride channel, TMEM16B, may support these dual roles in OSNs. We used multiphoton microscopy to image the stimulus-response density of OSNs in the olfactory epithelium. In TMEM16B knockout mice, we found that sensory representations were denser, and the magnitude of OSN responses was increased. Behaviorally, these changes in sensory representations were associated with an increased aversion to the odorant trimethylamine, which switches perceptual valence as its concentration increases, and a decreased efficiency of olfactory-guided navigation. Together, our results indicate that the calcium-activated chloride channel TMEM16B sparsens sensory representations in the peripheral olfactory system and contributes to efficient integrative olfactory-guided behaviors.

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Amplification of olfactory transduction currents implements sparse stimulus encoding

Belonio,

Haile,

Fyke

et al. 2024

Preprint

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Shaping smell: chloride currents dictate the kinetics of olfactory transduction

Cited by 1 publication

References 5 publications

Amplification of olfactory transduction currents implements sparse stimulus encoding

Amplification of olfactory transduction currents implements sparse stimulus encoding

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