Shared and distinct structural brain alterations and cognitive features in drug-naïve schizophrenia and bipolar disorder

Zhang, Wei; Du, Jinglun; Fang, Xing-yu; Ni, Long-yan; Zhu, Yuanyuan; Yan, Wei; Lu, Shuiping; Zhang, Rongrong; Xie, Shusen

doi:10.1016/j.ajp.2023.103513

Cited by 3 publications

(2 citation statements)

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“…Compared with patients with irritable bowel syndrome and healthy controls, the TH of the postcentral was considerably increased and positively associated with symptom duration in patients with colitis, thus supporting our proposed hypotheses ( 35 ). Meanwhile, we assume that a thickened postcentral may not be the primary cause of neuropsychiatric disorders in IBD patients as what constitutes the underlying pathophysiological mechanisms of cognitive impairment is its thinning structure ( 36 ). Further investigations are required to determine whether changes in specific cortices, such as the inferior parietal and postcentral regions, are implicated in psychosis triggered by chronic colitis.…”

Section: Discussionmentioning

confidence: 99%

Causality between inflammatory bowel disease and the cerebral cortex: insights from Mendelian randomization and integrated bioinformatics analysis

Peng

Chen

et al. 2023

Front. Immunol.

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BackgroundInflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic, progressive, and recurrent intestinal condition that poses a significant global health burden. The high prevalence of neuropsychiatric comorbidities in IBD necessitates the development of targeted management strategies.MethodsLeveraging genetic data from genome-wide association studies and Immunochip genotype analyses of nearly 150,000 individuals, we conducted a two-sample Mendelian randomization study to elucidate the driving force of IBD, UC, and CD on cortical reshaping. Genetic variants mediating the causality were collected to disclose the biological pathways linking intestinal inflammation to brain dysfunction.ResultsHere, 115, 69, and 98 instrumental variables genetically predicted IBD, UC, and CD. We found that CD significantly decreased the surface area of the temporal pole gyrus (β = −0.946 mm2, P = 0.005, false discovery rate-P = 0.085). Additionally, we identified suggestive variations in cortical surface area and thickness induced by exposure across eight functional gyri. The top 10 variant-matched genes were STAT3, FOS, NFKB1, JAK2, STAT4, TYK2, SMAD3, IL12B, MYC, and CCL2, which are interconnected in the interaction network and play a role in inflammatory and immune processes.ConclusionWe explore the causality between intestinal inflammation and altered cortical morphology. It is likely that neuroinflammation-induced damage, impaired neurological function, and persistent nociceptive input lead to morphological changes in the cerebral cortex, which may trigger neuropsychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Causality between inflammatory bowel disease and the cerebral cortex: insights from Mendelian randomization and integrated bioinformatics analysis

Peng

Chen

et al. 2023

Front. Immunol.

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“…Kim et al concluded that at least 85% of patients with schizophrenia have persistent and severe cognitive impairment, especially in attention, verbal memory, and executive functioning [20]. Compared with other psychiatric diseases, schizophrenia patients have more severe cognitive impairments such as language ability and operational ability, and their social function is worse [21]. The clinical symptoms of schizophrenia patients are a kind of protracted During the continuous process, the patient is always in a state of relatively poor social function, and often shows obvious symptoms of mental decline, and in severe cases, it gradually develops into mental disability [22].…”

Section: Clinical Manifestationmentioning

confidence: 99%

Research progress of cognitive impairment in schizophrenia

Liu

2023

Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022)

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Schizophrenia is a common type of mental illness that is difficult to diagnose and describe in psychiatric consultations. The symptoms of schizophrenia are categorized into three main categories: positive, negative, and cognitive impairment. These symptoms are considered the core clinical symptoms of the condition, and cognitive impairment is becoming a direction for further research on this subject. This article aims to review the various aspects of schizophrenia's cognitive impairment and provide a diagnosis and treatment guide for this condition.

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Advances in brain and religion studies: a review and synthesis of recent representative studies

McNamara,

Grafman

2024

Front. Hum. Neurosci.

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We review and synthesize recent religion and brain studies and find that at a broad network neuroscience level, religious/spiritual experiences (RSEs) appear to depend crucially upon interactions between the default mode network (DMN), the frontoparietal network (FPN), and the salience network (SN). We see this general result as broadly consistent with Menon’s et al. “Triple Network or Tripartite Model” (TPM) of neuropsychiatric function/dysfunction. A TPM cycling model is here offered to account for details of neural bases of an array of RSE phenomena including ecstatic seizures, neuroimaging of religious participants, psychedelically induced mystical states and perceptions of supernatural agents. To adequately account for SA perceptions, however, recent evidence suggests that REM sleep and dreaming mechanisms likely play a role. Future research should examine neurodevelopmental mechanisms of acquired SA perceptions as well as societal-level effects such as brain mediated religious beliefs of in-group cohesion and out-group hostility.

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Shared and distinct structural brain alterations and cognitive features in drug-naïve schizophrenia and bipolar disorder

Cited by 3 publications

References 73 publications

Causality between inflammatory bowel disease and the cerebral cortex: insights from Mendelian randomization and integrated bioinformatics analysis

Causality between inflammatory bowel disease and the cerebral cortex: insights from Mendelian randomization and integrated bioinformatics analysis

Research progress of cognitive impairment in schizophrenia

Advances in brain and religion studies: a review and synthesis of recent representative studies

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