2024
DOI: 10.1186/s12934-024-02309-0
|View full text |Cite|
|
Sign up to set email alerts
|

Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids

Marta N. Mota,
Madalena Matos,
Nada Bahri
et al.

Abstract: Background The improvement of yeast tolerance to acetic, butyric, and octanoic acids is an important step for the implementation of economically and technologically sustainable bioprocesses for the bioconversion of renewable biomass resources and wastes. To guide genome engineering of promising yeast cell factories toward highly robust superior strains, it is instrumental to identify molecular targets and understand the mechanisms underlying tolerance to those monocarboxylic fatty acids. A chem… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
5
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

1
0

Authors

Journals

citations
Cited by 1 publication
(5 citation statements)
references
References 110 publications
(177 reference statements)
0
5
0
Order By: Relevance
“…Remarkably, unlike most eukaryotes, deletion of genes coding for any of the subunits or assembly factors ( vma mutants) in S. cerevisiae does not lead to lethality under nonstressing conditions. However, it renders cells extremely sensitive to pH fluctuations, unable to grow on nonfermentable carbon sources, and susceptible to stress induced by a wide range of inhibitors, in particular acetic acid and other weak acids, and heavy metals (Kawahata et al 2006 , Kane 2007 , Mira et al 2010b , Tarsio et al 2011 , Deprez et al 2021 , Mota et al 2024 ).…”
Section: Homeostasis and Regulation Of Proton (H + ...mentioning
confidence: 99%
See 4 more Smart Citations
“…Remarkably, unlike most eukaryotes, deletion of genes coding for any of the subunits or assembly factors ( vma mutants) in S. cerevisiae does not lead to lethality under nonstressing conditions. However, it renders cells extremely sensitive to pH fluctuations, unable to grow on nonfermentable carbon sources, and susceptible to stress induced by a wide range of inhibitors, in particular acetic acid and other weak acids, and heavy metals (Kawahata et al 2006 , Kane 2007 , Mira et al 2010b , Tarsio et al 2011 , Deprez et al 2021 , Mota et al 2024 ).…”
Section: Homeostasis and Regulation Of Proton (H + ...mentioning
confidence: 99%
“…Notably, the activity of Pma1 is reduced in vma mutants, resulting either from Pma1 internalization, as a compensatory mechanism, or due to limitations in its activity through yet unidentified mechanisms (Kane 2016 , Wilms et al 2017 ). V-ATPase activity is crucial for yeast adaptation to acetic acid stress, as vma mutants are not able to recover the initial pHi drop induced by this acid and resume growth (Carmelo et al 1997 , Kawahata et al 2006 , Mira et al 2010b , Tarsio et al 2011 , Wilms et al 2017 , Deprez et al 2021 , Mota et al 2024 ). Overall, the coordination of Pma1 and V-ATPase activity represents a vital mechanism for maintaining pH homeostasis within the cell, in the absence or presence of acetic acid stress.…”
Section: Homeostasis and Regulation Of Proton (H + ...mentioning
confidence: 99%
See 3 more Smart Citations