IntroductionTotal joint replacement is the optimal treatment option for patients with severe haemophilic arthritis. Current research emphasizes patient‐reported outcomes as a vital measure for evaluating surgical outcomes and patient satisfaction. Nevertheless, very limited information about the subjective experience of perioperative haemophiliacs in the literature, highlighting the need for exploration in this area.AimTo investigate the psychological experiences and health demands of haemophilic arthropathy patients during the perioperative period of total joint replacement.DesignQualitative descriptive research with semistructured individual interviews.MethodsFrom June to September 2023, nine patients with severe haemophilic arthropathy who underwent total joint replacement at a Haemophilia Diagnosis and Treatment Centre in China were interviewed for average 37 min per person. Data were analysed using the traditional content analysis method and reported following the consolidated criteria for reporting qualitative research. The study is reported according to the COREQ checklist.ResultsInterviews described two main themes: (1) emotional decline which involves preoperative overoptimism, early postoperative anxiety and disease uncertainty during the early independent rehabilitation. (2) wellness aspiration which includes rehabilitation support and spiritual healing.ConclusionThis study reveals the patients’ significant psychological changes and their well‐being aspiration, particularly out‐of‐hospital rehabilitation needs. Strengthening communication between multidisciplinary teams and patients, enhancing the involvement of nurses, broadening the scope of functions at primary Haemophilia Treatment Centres, and developing telerehabilitation, these concerted efforts may improve the overall treatment experience for patients.