Intrapreneurship became a research topic of wide academic interest in recent times. The related subjects studied include its positive impact on organizations, the required working environments and external conditions as well as its impact on employees' behavior, motivation, etc. However, research on the potential barriers and risks related to intrapreneurship remains low. As recent studies tend to focus on single influence factors, there might also be a lack of systematic approaches to study the phenomena, acknowledging the variety of interdependent variables. This paper therefore suggests a systems theory-based approach to assess possible barriers of intrapreneurship in organizations under consideration of risk, systems and organizational behavior. After an outline of previous work on intrapreneurship in general and possible related threads and risk specifically, the sensitivity analysis method of Vester (2000) is adapted to develop a draft model of interconnected influence factors for intrapreneurial activities in organizations. This conceptual model should serve as a basis for further empirical research on the subject and supports the understanding of interdependencies between variables in an organisational system. The application of the model in a single-case study suggests that the influence factors 1) market situation, 2) attitude of employees, 3) skills and creativity, 4) values and goals of the organization, 5) working environment, 6) agility and rule breaking tolerance, 7) managerial processes or management support, 8) communication processes, 9) knowledge and 10) intangible assets could have a high impact on intrapreneurial activities. Future research could make use of this approach and empirically validate the conceptual model. It could be further enhanced through semantic modelling to illustrate the network of interdependencies.