Shared genetic and epigenetic mechanisms between chronic periodontitis and oral squamous cell carcinoma

Li, Simin; Liu, Xiangqiong; Zhou, Yu; Acharya, Aneesha; Savkovic, Vuk; Xu, Congling; Wu, Ning; Deng, Yupei; Hu, Xianda; Li, Hanluo; Haak, Rainer; Schmidt, Jana; Shang, Wei; Pan, Hongying; Ren, Shangping; Ye, Yu; Ziebolz, Dirk; Schmalz, Gerhard

doi:10.1016/j.oraloncology.2018.09.029

Cited by 40 publications

(53 citation statements)

References 51 publications

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“…The inflammation‐associated cancers have been linked to the interaction between microbial infection, either bacterial or viral, and inflammatory response mediators such as cytokines, reactive oxygen species, reactive nitrogen species, and growth factors, including vascular endothelial growth factor and epidermal growth factor . As a consequence, genetic and epigenetic changes in various proto‐oncogenes and tumor‐suppressor genes have been detected . A relatively stable epigenetic change may lead to the enhancement of tumorigenesis aspects such as faster cellular proliferation, stimulation of greater angiogenesis, and inhibition of apoptosis …”

Section: The Role Of Infection and Inflammatory Mediators In Cancer Dmentioning

confidence: 99%

“…As a consequence, genetic and epigenetic changes in various proto‐oncogenes and tumor‐suppressor genes have been detected . A relatively stable epigenetic change may lead to the enhancement of tumorigenesis aspects such as faster cellular proliferation, stimulation of greater angiogenesis, and inhibition of apoptosis …”

Section: The Role Of Infection and Inflammatory Mediators In Cancer Dmentioning

confidence: 99%

“…[64][65][66][67] As a consequence, genetic and epigenetic changes in various protooncogenes and tumor-suppressor genes have been detected. 60 A relatively stable epigenetic change may lead to the enhancement of tumorigenesis aspects such as faster cellular proliferation, stimulation of greater angiogenesis, and inhibition of apoptosis. 60,68 TA B L E 1 Periodontal disease-related genes with altered methylation patterns as hypermethylation (red) and hypomethylation (green), and their possible roles in cancer Also, it has been recently reported that periodontal pathogens were considered as an independent risk factor for oral cavity squamous cell carcinoma in nonsmoking, nonalcoholic, and human papillomavirus-negative patients.…”

Section: The Role Of Infec Ti On and Infl Ammatory Med Iator S In Cmentioning

confidence: 99%

“…60 A relatively stable epigenetic change may lead to the enhancement of tumorigenesis aspects such as faster cellular proliferation, stimulation of greater angiogenesis, and inhibition of apoptosis. 60,68 TA B L E 1 Periodontal disease-related genes with altered methylation patterns as hypermethylation (red) and hypomethylation (green), and their possible roles in cancer Also, it has been recently reported that periodontal pathogens were considered as an independent risk factor for oral cavity squamous cell carcinoma in nonsmoking, nonalcoholic, and human papillomavirus-negative patients. 71 The results indicated that microbiome-mediated inflammation may lead to oncogenesis, possibly through heat shock protein 90 (HSP90) or triggering toll-like receptor pathways in individuals with no major risk factors for oral cancer.…”

Section: The Role Of Infec Ti On and Infl Ammatory Med Iator S In Cmentioning

confidence: 99%

“…It should be noted that although chronic periodontitis has been found associated with cancers, chronic periodontitis has not been considered as the precancerous condition. [59][60][61][62]72 Bioinformatic data sets are a valuable source for detecting ge- In another study 73…”

Section: The Role Of Infec Ti On and Infl Ammatory Med Iator S In Cmentioning

confidence: 99%

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Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesis

Barros

Fahimipour

Tarran

et al. 2019

Periodontology 2000

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Periodontitis is a chronic multifactorial inﬂammatory disease associated with microbial dysbiosis and characterized by progressive destruction of the periodontal tissues. Such chronic infectious inflammatory disease is recognized as a major public health problem worldwide with measurable impact in systemic health. It has become evident that the periodontal disease phenotypes are not only determined by the microbiome effect, but the extent of the tissue response is also driven by the host genome and epigenome patterns responding to various environmental exposures. More recently there is mounting evidence indicating that epigenetic reprogramming in response to combined intrinsic and environmental exposures, might be particularly relevant due its plasticity and potential application towards precision health. The complex epigenetic crosstalk is reflected in the prognosis and progress of periodontal diseases and may also lead to a favorable landscape for cancer development. This review discusses epigenomics modifications focusing on the role of DNA methylation and pathways linking microbial infection and inflammatory pathways, which are also associated with carcinogenesis. There is a more clear vision whereas 'omics' technologies applied to unveil relevant epigenetic factors could play a significant role in the treatment of periodontal disease in a personalized mode, evidencing that public health approach should coexist with precision individualized treatment.

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Section: The Role Of Infection and Inflammatory Mediators In Cancer Dmentioning

confidence: 99%

Section: The Role Of Infection and Inflammatory Mediators In Cancer Dmentioning

confidence: 99%

Section: The Role Of Infec Ti On and Infl Ammatory Med Iator S In Cmentioning

confidence: 99%

Section: The Role Of Infec Ti On and Infl Ammatory Med Iator S In Cmentioning

confidence: 99%

Section: The Role Of Infec Ti On and Infl Ammatory Med Iator S In Cmentioning

confidence: 99%

See 3 more Smart Citations

Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesis

Barros

Fahimipour

Tarran

et al. 2019

Periodontology 2000

View full text Add to dashboard Cite

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Identification of biomarkers related to glycolysis with weighted gene co‐expression network analysis in oral squamous cell carcinoma

2021

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Background Oral squamous cell carcinoma (OSCC) is the most common tumor in the oral cavity and maxillofacial region. Increasing evidence suggests that aerobic glycolysis plays an important role in the occurrence, development, and prognosis of OSCC. Therefore, the identification of biomarkers related to glycolysis in OSCC represents considerable potential for improving its treatment. Methods In the present study, a single‐sample gene‐set enrichment analysis (ssGSEA) algorithm with weighted gene co‐expression network analysis (WGCNA) were used to quantify the degree of glycolysis and identify key modules with the greatest correlation with glycolysis. Results Glycolytic scores significantly correlated with prognosis. In the key module 5 HUB genes were finally selected, which displayed a robust predictive effect. The expressions of key genes were associated with glycolysis. Conclusions The research comprehensively analyzed the glycolysis of OSCC and identified several biomarkers related to glycolysis. These biomarkers may represent potential therapeutic targets for future OSCC therapy.

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Oral microbial changes and oral disease management before and after the treatment of hematological malignancies: a narrative review

Lin

et al. 2023

Clin Oral Invest

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Shared genetic and epigenetic mechanisms between chronic periodontitis and oral squamous cell carcinoma

Cited by 40 publications

References 51 publications

Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesis

Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesis

Identification of biomarkers related to glycolysis with weighted gene co‐expression network analysis in oral squamous cell carcinoma

Oral microbial changes and oral disease management before and after the treatment of hematological malignancies: a narrative review

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