Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis

Zhang, Mengzhe; Gao, Xinyu; Yang, Zhengui; Wen, Mengmeng; Huang, Huiyu; Zheng, Ruiping; Wang, Weijian; Wei, Yarui; Cheng, Jingliang; Han, Shaoqiang; Zhang, Yong

doi:10.1007/s00213-021-05920-w

Cited by 100 publications

(22 citation statements)

References 111 publications

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“…The occipital lobe, such as lingual gyrus, fusiform gyrus, is the visual cortex involved in processing color information, face and body recognition, and emotion perception responding to facial stimuli ( 49 – 51 ). A large scale meta-analysis has demonstrated that individuals with substance addiction, such as tobacco, alcohol, and cocaine displayed higher gray matter volume in the right lingual gyrus and right fusiform gyrus relative to healthy controls ( 12 ). Previous studies observed the brain regions associated with visuospatial attention cortex (prefrontal cortex and fusiform gyrus) were much more active after exposure to smoking-related images than neutral images in long-term smokers ( 52 ).…”

Section: Discussionmentioning

confidence: 99%

“…Continuously, tobacco abuse impairs brain function by disturbing the ability of self-control, which turns initial voluntary action into the automatic and compulsive behavior that characterizes addiction ( 10 , 11 ). A meta-analysis found that substance addiction subjects (e.g., tobacco, cocaine, and alcohol) showed decreased gray matter volume in the orbitofrontal cortex (OFC), insula, anterior cingulate (ACC), and striatum ( 12 ). A recent study on smoking cessation suggested that repeated tobacco exposure could “hijack” natural reward circuitry by increasing the desire to obtain tobacco, and smoking cessation would restore striatal resting-state functional connectivity ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

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Weight Status Modulated Brain Regional Homogeneity in Long-Term Male Smokers

et al. 2022

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BackgroundTobacco smoking and being overweight could lead to adverse health effects, which remain an important public health problem worldwide. Research indicates that overlapping pathophysiology may contribute to tobacco addiction and being overweight, but the neurobiological interaction mechanism between the two factors is still unclear.MethodsThe current study used a mixed sample design, including the following four groups: (i) overweight long-term smokers (n = 24); (ii) normal-weight smokers (n = 28); (iii) overweight non-smokers (n = 19), and (iv) normal-weight non-smokers (n = 28), for a total of 89 male subjects. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI). Regional homogeneity (ReHo) was used to compare internal cerebral activity among the four groups. Interaction effects between tobacco addiction and weight status on ReHo were detected using a two-way analysis of variance, correcting for age, years of education, and head motion.ResultsA significant interaction effect between tobacco addiction and weight status is shown in right superior frontal gyrus. Correlation analyses show that the strengthened ReHo value in the right superior frontal gyrus is positively associated with pack-year. Besides, the main effect of tobacco addiction is specially observed in the occipital lobe and cerebellum posterior lobe. As for the main effect of weight status, the right lentiform nucleus, left postcentral gyrus, and brain regions involved in default mode network (DMN) survived.ConclusionsThese results shed light on an antagonistic interaction on brain ReHo between tobacco addiction and weight status in the right superior frontal gyrus, which may be a clinical neuro-marker of comorbid tobacco addiction and overweight. Our findings may provide a potential target to develop effective treatments for the unique population of comorbid tobacco addiction and overweight people.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Weight Status Modulated Brain Regional Homogeneity in Long-Term Male Smokers

et al. 2022

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“…In summary, OFC plays a critical role in integrating multiple sources of information to guide decision‐making. As the result of the abnormal GMV in bilateral OFC, it may lead to a decline in the ability to integrate information and further bring about maladaptive decision‐making (Zhang et al, 2021). This could account for the propensity of seeking drugs and repetitive behaviors among individuals with TUD, despite the almost inevitable negative consequences of such behaviors.…”

Section: Discussionmentioning

confidence: 99%

Integrative brain structural and molecular analyses of interaction between tobacco use disorder and overweight among male adults

Zhang

Gao

Yang

et al. 2022

J of Neuroscience Research

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Tobacco smoking and overweight lead to adverse health effects, which remain an important public health problem worldwide. Researches indicate overlapping pathophysiology may contribute to tobacco use disorder (TUD) and overweight, but the neurobiological interaction mechanism between the two factors is still unclear. This study used a mixed sample design, including the following four groups: (i) overweight long-term smokers (n = 24, age = 31.80 ± 5.70, cigarettes/day = 20.50 ± 7.89); (ii) normal weight smokers (n = 28, age = 31.29 ± 5.56, cigarettes/day = 16.11 ± 8.35); (iii) overweight nonsmokers (n = 19, age = 33.05 ± 5.60), and (iv) normal weight nonsmok-ers (n = 28, age = 31.68 ± 6.57), a total of 99 male subjects. All subjects underwent T1-weighted high-resolution MRI. We used voxel-based morphometry to compare gray matter volume (GMV) among the four groups. Then, JuSpace toolbox was used for cross-modal correlations of MRI-based modalities with nuclear imaging derived estimates, to examine specific neurotransmitter system changes underlying the two factors. Our results illustrate a significant antagonistic interaction between TUD and weight status in left dorsolateral prefrontal cortex (DLPFC), and a quadratic effect of BMI on DLPFC GMV. For main effect of TUD, long-term smokers were associated with greater GMV in bilateral OFC compared with nonsmokers irrespective of weight status, and such alteration is negatively associated with pack-year and FTND scores. Furthermore, we also found GMV changes related to TUD and overweight are associated with μ-opioid receptor system and TUD-related GMV alterations are associated with noradrenaline transporter maps. This study sheds light on novel multimodal neuromechanistic about the relationship between TUD and overweight, which possibly provides hints into future treatment for the special population of comorbid TUD and overweight.

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“…Similarly, individuals with SUDs present neuroadaptations in the frontal-striatal circuitry with reduced GMV in the prefrontal cortex, ACC, bilateral insula, and thalamus [ 32 – 34 ]. Impairments in reward processing have been evidenced by functional abnormalities in the striatum involved in habit formation, compulsive behavior, and reinforcement learning [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Distinct brain structural abnormalities in attention-deficit/hyperactivity disorder and substance use disorders: A comparative meta-analysis

Long

Pan

et al. 2022

Transl Psychiatry

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As two common mental disorders during the period of adolescence that extend to early adulthood, attention-deficit/hyperactivity disorder (ADHD) and substance use disorders (SUDs) have considerable diagnostic co-occurrence and shared neuropsychological impairments. Our study aimed to identify overlapping and distinct brain structural abnormalities associated with ADHD and SUDs among adolescents and young adults. A systematic literature search on voxel-based morphometry (VBM) studies of ADHD and SUDs was conducted in PubMed and Web of Science. Data were extracted and analyzed to identify brain abnormalities using Seed-based d-Mapping software. Data-driven functional decoding was conducted to identify the psychophysiological functioning associated with brain alterations. 13 and 14 VBM studies for ADHD (619 patients and 483 controls) and SUDs (516 patients and 413 controls), respectively, were included. Patterns of decreased gray matter volume (GMV) were found in the left precentral gyrus, bilateral superior frontal gyri, and left inferior frontal gyrus in the ADHD group compared to the control group. In contrast, individuals with SUDs, relative to controls, were characterized by increased GMV in the left putamen and insula. Comparative analysis indicated larger regional GMV in the right inferior parietal lobule and smaller volumes in the left putamen and left precentral gyrus in the ADHD group than in the SUDs group. Dissociable brain structural abnormalities in adolescents and young adults with ADHD and SUDs potentially implicate different pathogeneses and provide a reference for differential diagnosis and early detection for shared symptomology and comorbidity.

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Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis

Cited by 100 publications

References 111 publications

Weight Status Modulated Brain Regional Homogeneity in Long-Term Male Smokers

Weight Status Modulated Brain Regional Homogeneity in Long-Term Male Smokers

Integrative brain structural and molecular analyses of interaction between tobacco use disorder and overweight among male adults

Distinct brain structural abnormalities in attention-deficit/hyperactivity disorder and substance use disorders: A comparative meta-analysis

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