Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention

Masoudkabir, Farzad; Mohammadifard, Noushin; Mani, Arya; Ignaszewski, Andrew; Davis, Margot K.; Vaseghi, Golnaz; Mansourian, Marjan; Franco, Christopher; Gotay, Carolyn; Sarrafzadegan, Nizal

doi:10.1155/2023/2404806

Cited by 8 publications

(3 citation statements)

References 130 publications

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“…As shared risk factors (Ma et al , 2010; Bardou et al , 2022), the effects of obesity, diabetes mellitus, hypertension and dyslipidemia on CRC may have overlapping mechanisms. Based on recent studies (Koene et al , 2016; Masoudkabir et al , 2023), chronic inflammation may play a key role which contributes to occurs in both above conditions and CRC.…”

Section: Discussionmentioning

confidence: 99%

Association between metabolic syndrome and the risk of colorectal cancer: a prospective study in China

Wang,

Chen,

Zhang

et al. 2023

European Journal of Cancer Prevention

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Objective To evaluate the correlation between metabolic syndrome (MetS) and its components on the incidence of colorectal cancer (CRC) based on data from Jinchang Cohort. Methods This is a large prospective cohort study. Between 2011 and 2020, a total of 43 516 individuals from Jinchang Cohort were included for this study. Hazard ratios (HRs) with 95% confidence intervals (CIs) for CRC according to MetS were calculated with the Cox proportional hazard models. The restricted cubic spine models with four knots were conducted to fit the dose-response relationships. Results MetS was associated with increased risk of CRC (n = 141; HR: 1.64, 95% CI: 1.15–2.33) after adjusting for confounding factors (age, sex, education level, family history of CRC, smoking index and alcohol index). Participants with hyperglycemia had a significantly higher risk of developing incident CRC (HR: 1.70; 95% CI: 1.19–2.43). The positive association between MetS and CRC was observed in males (HR: 1.76; 95% CI: 1.17–2.63), but not in females (HR: 1.24; 95% CI: 0.59–2.64). Furthermore, linear dose-response relationship was found between fasting plasma glucose (FPG) and CRC risk in males (P overall < 0.05, P non-linear = 0.35). When stratified by smoke and drink, MetS was found to increase the incidence of CRC only in the smoke (HR: 2.07, 95% CI: 1.35–3.18) and drink (HR: 2.93, 95% CI: 1.51–5.69) groups. Conclusion MetS was associated with a higher risk of CRC incidence. Hyperglycemia lended strong support to the role of MetS in new-onset CRC, especially in males. Other components of MetS were not found to be associated with increased risk of CRC.

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Section: Discussionmentioning

confidence: 99%

Association between metabolic syndrome and the risk of colorectal cancer: a prospective study in China

Wang,

Chen,

Zhang

et al. 2023

European Journal of Cancer Prevention

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“…Another study revealed that alcohol and tobacco have give-and-take impacts on despot hankering, "subjective responses to fixed-dose alcohol or nicotine administration and self-administration" [142]. Smoking and alcohol ingestion have been stated as considerable risk features for cardiovascular diseases (CVDs), cancers, type 2 diabetes mellitus (T2DM), obesity, bronchial asthma, stress, stroke, and other lifestyle-related noncommunicable diseases, and increasing mortalities [143][144][145]. WHO reported annually that around the globe, 7 and 3 million people died because of tobacco and alcohol consumption, respectively [146,147].…”

Section: Association Between Tobacco and Alcoholmentioning

confidence: 99%

Alcohol and Periodontal Disease: A Narrative Review

Gandhi,

Benjamin,

Gajjar

et al. 2024

Cureus

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“…Lifestyle modifications, such as adopting a healthy diet, engaging in regular physical activity, avoiding tobacco use, and managing stress, can significantly lower the risk of developing CVDs. Early detection, timely medical intervention, and access to quality healthcare services are essential for effectively managing CVDs and preventing complications 2 , 3 . Ischemic heart disease (IHD) is indeed a major cause of death among CVDs 4 .…”

Section: Introductionmentioning

confidence: 99%

A proposed tree-based explainable artificial intelligence approach for the prediction of angina pectoris

Guldogan,

Yagin,

Pinar

et al. 2023

Sci Rep

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Cardiovascular diseases (CVDs) are a serious public health issue that affects and is responsible for numerous fatalities and impairments. Ischemic heart disease (IHD) is one of the most prevalent and deadliest types of CVDs and is responsible for 45% of all CVD-related fatalities. IHD occurs when the blood supply to the heart is reduced due to narrowed or blocked arteries, which causes angina pectoris (AP) chest pain. AP is a common symptom of IHD and can indicate a higher risk of heart attack or sudden cardiac death. Therefore, it is important to diagnose and treat AP promptly and effectively. To forecast AP in women, we constructed a novel artificial intelligence (AI) method employing the tree-based algorithm known as an Explainable Boosting Machine (EBM). EBM is a machine learning (ML) technique that combines the interpretability of linear models with the flexibility and accuracy of gradient boosting. We applied EBM to a dataset of 200 female patients, 100 with AP and 100 without AP, and extracted the most relevant features for AP prediction. We then evaluated the performance of EBM against other AI methods, such as Logistic Regression (LR), Categorical Boosting (CatBoost), eXtreme Gradient Boosting (XGBoost), Adaptive Boosting (AdaBoost), and Light Gradient Boosting Machine (LightGBM). We found that EBM was the most accurate and well-balanced technique for forecasting AP, with accuracy (0.925) and Youden's index (0.960). We also looked at the global and local explanations provided by EBM to better understand how each feature affected the prediction and how each patient was classified. Our research showed that EBM is a useful AI method for predicting AP in women and identifying the risk factors related to it. This can help clinicians to provide personalized and evidence-based care for female patients with AP.

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Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention

Cited by 8 publications

References 130 publications

Association between metabolic syndrome and the risk of colorectal cancer: a prospective study in China

Association between metabolic syndrome and the risk of colorectal cancer: a prospective study in China

Alcohol and Periodontal Disease: A Narrative Review

A proposed tree-based explainable artificial intelligence approach for the prediction of angina pectoris

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