Shared neural substrates of apraxia and aphasia

Goldenberg, Georg; Randerath, Jennifer

doi:10.1016/j.neuropsychologia.2015.05.017

Cited by 107 publications

(89 citation statements)

References 77 publications

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“…Therefore, the current results showing a significant association between the reduction (severe apraxia) of the AST score and lesions in the left IFG and IPL were consistent with the findings of previous stimulation studies. Previous lesion studies related to apraxia reported that lesions in the left IPL (21, 22, 69, 100–102), left IFG (39, 102, 103), left insula (104), and left precentral gyrus (102) were significantly associated with an impairment of transitive gestures (pantomime). These previous studies, in line with the current results, were performed using brain lesion areas associated with ipsilateral limb errors (apraxic symptoms).…”

Section: Discussionmentioning

confidence: 97%

“…In consideration of the frequent occurrence of apraxia and aphasia (69), we evaluated the presence of aphasia in the patients using the standard language test of aphasia (SLTA) (70) and the supplementary tests for the SLTA (SLTA-ST) (71) to be certain that the patients could understand and respond to the experimental task. The SLTA is the only aphasia test standardized in Japan.…”

Section: Methodsmentioning

confidence: 99%

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Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

et al. 2018

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Limb apraxia is a higher brain dysfunction that typically occurs after left hemispheric stroke and its cause cannot be explained by sensory disturbance or motor paralysis. The comparison of motor signals and visual feedback to generate errors, i.e., visuo-motor integration, is important in motor control and motor learning, which may be impaired in apraxia. However, in apraxia after stroke, it is unknown whether there is a specific deficit in visuo-motor temporal integration compared to visuo-tactile and visuo-proprioceptive temporal integration. We examined the precision of visuo-motor temporal integration and sensory-sensory (visuo-tactile and visuo-proprioception) temporal integration in apraxia after stroke by using a delayed visual feedback detection task with three different conditions (tactile, passive movement, and active movement). The delay detection threshold and the probability curve for delay detection obtained in this task were quantitative indicators of the respective temporal integration functions. In addition, we performed subtraction and voxel-based lesion-symptom mapping to identify the brain lesions responsible for apraxia and deficits in visuo-motor temporal integration. The behavioral experiments showed that the delay detection threshold was extended and that the probability curve for delay detection was less steep in apraxic patients compared to controls (pseudo-apraxic patients and unaffected patients), only for the active movement condition, and not for the tactile and passive movement conditions. Furthermore, the severity of apraxia was significantly correlated with the delay detection threshold and the steepness of the probability curve in the active movement condition. These results indicated that multisensory (i.e., visual, tactile, and proprioception) feedback was normally temporally integrated, but motor prediction and visual feedback were not correctly temporally integrated in apraxic patients. That is, apraxic patients had difficulties with visuo-motor temporal integration. Lesion analyses revealed that both apraxia and the distortion of visuo-motor temporal integration were associated with lesions in the fronto-parietal motor network, including the left inferior parietal lobule and left inferior frontal gyrus. We suppose that damage to the left inferior fronto-parietal network could cause deficits in motor prediction for visuo-motor temporal integration, but not for sensory-sensory (visuo-tactile and visuo-proprioception) temporal integration, leading to the distortion of visuo-motor temporal integration in patients with apraxia.

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Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

et al. 2018

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“…In healthy controls, the hippocampus was detected as important also for encoding and retrieval of event related memories (Eldridge et al, 2000) and context coding (Kalisch et al, 2006). Moreover, the hippocampus as well as the MTG seem to play important roles in retrieval of semantic knowledge about the use of a tool (Goldenberg and Randerath, 2015). Thus, corresponding lesions can cause pantomime impairments and lead to ideo-motor apraxia (Speach et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Altered praxis network underlying limb kinetic apraxia in Parkinson's disease - an fMRI study

Kübel

Stegmayer

Vanbellingen

et al. 2017

NeuroImage: Clinical

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Parkinson's disease (PD) patients frequently suffer from dexterous deficits impeding activities of daily living. There is controversy whether impaired fine motor skill may stem from limb kinetic apraxia (LKA) rather than bradykinesia. Based on classical models of limb praxis LKA is thought to result when premotor transmission of time-space information of skilled movements to primary motor representations is interrupted. Therefore, using functional magnetic resonance imaging (fMRI) we tested the hypothesis that dexterous deficits in PD are associated with altered activity and connectivity in left parieto-premotor praxis network. Whole-brain analysis of fMRI activity during a task for LKA (coin rotation) showed increased activation of superior and inferior parietal lobule (SPL, IPL) and ventral premotor cortex (vPM) in PD patients compared to controls. For bradykinesia (assessed by finger tapping) a decreased fMRI activity could be detected in patients. Additionally, psychophysical interaction analysis showed increased functional connectivity between IPL and the posterior hippocampi in patients with PD. By contrast, functional connectivity to the right dorsolateral prefrontal cortex was decreased in patients with PD compared to controls.In conclusion, our data demonstrates that dexterous deficits in PD were associated with enhanced fMRI activation of the left praxis network upstream to primary motor areas, mirroring a neural correlate for the behavioral dissociation of LKA and bradykinesia. Furthermore, the findings suggest that patients recruit temporal areas of motor memory as an attempt to compensate for impaired motor skills. Finally, dysexecutive function may contribute to the deficit.

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“…This might be due to the suggestion that the left hemisphere is responsible for the conceptualization of representational gestures (Helmich & Lausberg, 2014). The importance of left hemisphere for tool-related and imitational gestures also provides support for this notion (Goldenberg & Randerath, 2015). Conversely, right hemisphere damage is associated with the deficits of rhythmic gestures (Blonder et al, 1995; Cocks et al, 2007; Hogrefe et al, 2016; Rousseaux et al, 2010) along with other nonverbal and non-motor aspects of communication such as intonation and prosody (Lausberg, Zaidel, Cruz, & Ptito, 2007; Shapiro & Danly, 1985).…”

Section: Introductionmentioning

confidence: 85%

The relationship between co-speech gesture production and macrolinguistic discourse abilities in people with focal brain injury

et al. 2018

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Brain damage is associated with linguistic deficits and might alter co-speech gesture production. Gesture production after focal brain injury has been mainly investigated with respect to intrasentential rather than discourse-level linguistic processing. In this study, we examined 1) spontaneous gesture production patterns of people with left hemisphere damage (LHD) or right hemisphere damage (RHD) in a narrative setting, 2) the neural structures associated with deviations in spontaneous gesture production in these groups, and 3) the relationship between spontaneous gesture production and discourse level linguistic processes (narrative complexity and evaluation competence). Individuals with LHD or RHD (17 people in each group) and neurotypical controls (n = 13) narrated a story from a picture book. Results showed that increase in gesture production for LHD individuals was associated with less complex narratives and lesions of individuals who produced more gestures than neurotypical individuals overlapped in frontal-temporal structures and basal ganglia. Co-speech gesture production of RHD individuals positively correlated with their evaluation competence in narrative. Lesions of RHD individuals who produced more gestures overlapped in the superior temporal gyrus and the inferior parietal lobule. Overall, LHD individuals produced more gestures than neurotypical individuals. The groups did not differ in their use of different gesture forms except that LHD individuals produced more deictic gestures per utterance than RHD individuals and controls. Our findings are consistent with the hypothesis that co-speech gesture production interacts with macro-linguistic levels of discourse and this interaction is affected by the hemispheric lateralization of discourse abilities.

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Shared neural substrates of apraxia and aphasia

Cited by 107 publications

References 77 publications

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

Altered praxis network underlying limb kinetic apraxia in Parkinson's disease - an fMRI study

The relationship between co-speech gesture production and macrolinguistic discourse abilities in people with focal brain injury

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