2008
DOI: 10.1016/j.cell.2008.01.020
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Shared Principles in NF-κB Signaling

Abstract: The transcription factor NF-kappaB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-kappaB, and the large number of genes regulated by NF-kappaB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation.

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Cited by 4,221 publications
(4,030 citation statements)
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References 173 publications
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“…TAK1-NF-kB pathway: TAK1 is a well-documented upstream kinase of NF-kB. 3,6,7 NF-kB transcriptionally upregulates antiapoptotic protein such as c-FLIP and IAP family proteins ( Figure 1). The IAP family includes cIAP1, cIAP2 and XIAP, which can inhibit caspase activation.…”
Section: Tak1 Inhibits Apoptosismentioning
confidence: 99%
See 1 more Smart Citation
“…TAK1-NF-kB pathway: TAK1 is a well-documented upstream kinase of NF-kB. 3,6,7 NF-kB transcriptionally upregulates antiapoptotic protein such as c-FLIP and IAP family proteins ( Figure 1). The IAP family includes cIAP1, cIAP2 and XIAP, which can inhibit caspase activation.…”
Section: Tak1 Inhibits Apoptosismentioning
confidence: 99%
“…TAK1 has a powerful prosurvival role in activating the Ikb kinase (IKK)-NF-kB pathway, which has a number of target genes, many of which block apoptosis, promote cell proliferation and stimulate inflammatory responses. [1][2][3] Loss of TAK1 sensitizes cells to death through many of the myriad pathways known to activate TAK1, including TNFa. However, accumulating results suggest that TAK1 is essential for cell survival, above and beyond its role in NF-kB activation through pathways that are discussed in this review.…”
mentioning
confidence: 99%
“…NF-kB is a latent cytoplasmic transcription factor whose activation is regulated via control of nuclear translocation through the signal-induced degradation of inhibitory proteins (Hayden and Ghosh, 2008). Two main NF-kB-activating signalling pathways have been characterized and referred to as the 'classical' or 'canonical' pathway and the 'alternative' or 'non-canonical' pathway (Bonizzi and Karin, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…P65 is one of the NF‐κB family of transcription factors, which participates in various biological processes, including immune response, inflammation, development, cell growth, and survival (Hayden & Ghosh, 2008; Vallabhapurapu & Karin, 2009). As one of the most abundant and well‐characterized NF‐κB dimer, P65 (RelA) translocate to nuclear and drive transcriptional response (Hayden & Ghosh, 2008; Karin & Ben‐Neriah, 2000; Vallabhapurapu & Karin, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…As one of the most abundant and well‐characterized NF‐κB dimer, P65 (RelA) translocate to nuclear and drive transcriptional response (Hayden & Ghosh, 2008; Karin & Ben‐Neriah, 2000; Vallabhapurapu & Karin, 2009). Phosphorylated form of P65/RelA is specifically required to activate transcriptional responses, including inflammatory response (Jamaluddin, Wang, Boldogh, Tian, & Brasier, 2007; Nicodeme et al., 2010; Nowak et al., 2008; Vermeulen, De Wilde, Van Damme, Vanden Berghe, & Haegeman, 2003; Zhong, SuYang, Erdjument‐Bromage, Tempst, & Ghosh, 1997).…”
Section: Discussionmentioning
confidence: 99%