Sharing Pathological Mechanisms of Insomnia and Osteoporosis, and a New Perspective on Safe Drug Choice

Abstract

Lack of adequate sleep has become increasingly common in our 24/7 modern society. Reduced sleep has significant health consequences including metabolic and cardiovascular disorders, and mental problems including depression. In addition, although the increase in life expectancy has provided a dream of longevity to humans, the occurrence of osteoporosis is a big obstacle to this dream for both male and female. It is known that insomnia and bone health problems, which are very critical conditions in human life, interestingly, share a lot of pathogenesis in recent decades. Nevertheless, due to another side effects of the synthetic drugs being taken for the treatment of insomnia and osteoporosis, patients have substantial anxiety for the safety of drugs with therapeutic expectation. This review examines the pathogenesis shared by sleep and osteoporosis together and herbal medicine, which has recently been shown to be safe and efficacious in the treatment of both diseases other than synthetic drugs. We suggestions for how to treat osteoporosis. These efforts will be the first step toward enabling patients to have comfortable and safe prescriptions through a wide selection of therapeutic agents in the future.

Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions for Insomnia: A Perspective

“…Thus, a combined low BMD and TBS representing the high frequency of osteoporotic fractures may be associated with insomnia [ 214 ]. The underlying possible mechanisms may include insomnia-mediated dysregulation of the hypothalamo-pituitary-adrenal (HPA) axis due to increased secretion of cortisol, altered levels of hormones (orexins, ghrelin, serotonin, melatonin), and stress-related metabolic alterations with its resultant impact on the sympathetic system [ 215 ].…”

Self-Reported Sleeping Time Effects on Physical Performance and Body Composition Among Spanish Older Adults: EXERNET-Elder 3.0 study

“…Several studies have shown associations between inadequate nocturnal sleep and negative health factors ( Foley et al, 2004 ; Goldman et al, 2007 ). In fact, repetitive sleep deprivation (<6 hours/day) is associated with endocrine and immune dysregulations and cognitive decline ( Tumiran et al, 2018 ), which increase the prevalence of chronic diseases such as diabetes ( Tan et al, 2018 ), metabolic syndrome ( Tan et al, 2018 ), obesity ( Tan et al, 2019 ), osteoporosis ( Yi et al, 2018 ), heart disease ( Foley et al, 2004 ), neurodegenerative diseases ( Wei et al, 2019 ), and even mortality ( Stone et al, 2009 ).…”