Sharing via Low-Cost Discovery in Global Effort for Combat Diseases: Simple Chemical Routes for Lead Compounds Using Biomass Driven Building Blocks.

Abstract

A MONG various participations in the global efforts for drugs, preservatives and pesticides discovery, there are cost-effective simple synthetic routes via productive methods to synthesize potent biologically active compounds, utilizing biomass driven starting compounds. This eco-friendly approach appropriates also researchers where shortage in research fund and facilities. Versatile precursors such as 3-oxoalkane carboxylates, activated nitriles and a,β unsaturated ketones, were utilized for the facile synthesis of various biologically interesting small molecules. In this review, we highlight representative synthetic findings for bioactive leads arising from our continuous attempts with this approach. Further development by industry and academia through lead optimization will produce new active ingredients to face contiguous hazard biological challenges and resistance of microbes and insects. Many other researchers have made many great achievements in each of these subjects, but these are beyond the scope of this review.

Utility of a New Non-Toxic Antibacterial Cellulose Membrane Prepared via Casting Technique

“…In our previous studies we aimed to synthesize new biologically active compounds [22][23][24][25], Non-toxic antibacterial cyanoacetyl microcrystalline cellulose (NACAMC) was synthesized utilizing rice straw pulp [26][27][28]. In the present work, this novel green biologically active compound (NACAMC) was blended with cellulose acetate in an attempt to prepare antibacterial membranes and studying their chemical and physical properties..…”

Utility of copper (lignin/silica/fatty acids) complex derived from rice straw as antioxidant/hardening and fluid resistant agent in nitrile-butadiene rubber composites (PART IV)

“…Great efforts have been done seeking for antioxidants and reinforcing agents to improve the rubber properties and make rubber more resistant to degradation. As our eco-friendly program in using wastes interests in finding low-cost biodegradable effective alternatives (Abdel Zaher et al , 2014, 2019; Nawwar et al , 2020; Othman et al , 2021) and active compounds (Allam and Nawwar, 2002; Heinisch et al , 1986; Yakout et al , 1999) for various applications (Nawwar et al , 2018), one of these efforts is the recent study (Othman et al , 2021) using a green low-cost antioxidant copper (lignin/silica/fatty acids) (Cu-LSF complex) resulted from using the black liquor of rice straw’s pulping process (Abdel Zaher et al , 2014; Nawwar et al , 2016). Incorporation of lignin and silica into the rubber matrix was reported to exhibit antioxidant activity and improve the rubber reinforcing and mechanical properties (Abdel Zaher et al , 2014, 2019).…”