2017
DOI: 10.1007/s11418-017-1086-5
|View full text |Cite
|
Sign up to set email alerts
|

Sharkquinone, a new ana-quinonoid tetracene derivative from marine-derived Streptomyces sp. EGY1 with TRAIL resistance-overcoming activity

Abstract: A new ana-quinonoid tetracene metabolite, named sharkquinone (1), and the known SS-228R (2) have been isolated from the ethyl acetate extract of the culture of marine Streptomyces sp. EGY1. The strain was isolated from sediment sample collected from the Red Sea coast of Egypt. The structure of sharkquinone (1) was elucidated using detailed spectral (HRESI-MS, 1D and 2D NMR) analyses and quantum chemical calculations. This is the first report of the isolation of ana-quinonoid tetracene derivative from a natural… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
6
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
5
1
1

Relationship

1
6

Authors

Journals

citations
Cited by 13 publications
(6 citation statements)
references
References 34 publications
0
6
0
Order By: Relevance
“…Working up of the strain led to the isolation of an ana-quinonoid tetracene derivative named sharkquinone ( 1 ). The structure of compound 1 ( Figure 1 B) was determined using spectral analysis including 1D NMR [ 31 ]. The strain EGY34 was isolated from a sediment sample collected from Ras Mohammed, South of Sinai, Egypt.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…Working up of the strain led to the isolation of an ana-quinonoid tetracene derivative named sharkquinone ( 1 ). The structure of compound 1 ( Figure 1 B) was determined using spectral analysis including 1D NMR [ 31 ]. The strain EGY34 was isolated from a sediment sample collected from Ras Mohammed, South of Sinai, Egypt.…”
Section: Resultsmentioning
confidence: 99%
“…Resistomycin was also found in other studies to induce significant cytotoxicity in the hepatic carcinoma (HepG2) and cervical carcinoma (Hela) cell lines, in vitro [ 41 ], and to enhance the apoptotic effect of colcemid (CL) in human megakaryoblastic leukemia CMK-7 cells [ 74 ]. Other secondary metabolites such as sharkquinone and elloxazinones A and B were found to induce apoptosis in human gastric adenocarcinoma (AGS) cells [ 31 ] and, albeit to a lesser extent, in the hepatocellular (HepG2) and breast (MCF-7) cancer cell lines [ 45 ]. Consistent with these studies, we demonstrate here that the secondary metabolites investigated in our study were all able to trigger apoptosis, alone, as evidenced by nuclear fragmentation and annexin V positivity in HCT116, Jurkat, and MDA-MB-231 cells.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Abdelfattah et al isolated a new ana-quinonoid tetracene metabolite from the ethyl acetate extract of the culture of marine bacteria Streptomyces sp. EGY1 and named it sharkquinone [141]. Sharkquinone sensitized TRAIL-resistant AGS cells and suggested their potential use in combination with TRAIL against AGS cells.…”
Section: Chemotherapy Resistance and Natural Products In Gastric Cancermentioning
confidence: 99%