Let Gu,v be a homogeneous nonnegative function of order λ,Kn,xm,ρ=Gnλ1,xm,ρλ2. By using the weight coefficient method, the equivalent parameter conditions and best constant factors for the validity of the following half-discrete Hilbert-type multiple integral inequality ∫ℝ+m ∑n=1∞ Kn,xm,ρanfxdx≤Ma~p,αfq,β are discussed. Finally, its applications in operator theory are discussed.