SHBG levels correlate with insulin resistance in postmenopausal women

Effects of Aerobic Exercise Training on Serum Sex Hormone Binding Globulin, Body Fat Index, and Metabolic Syndrome Factors in Obese Postmenopausal Women

“…However, TG and SBP were not associated with SHBG concentrations in obese postmenopausal Korean women. The current study's data are in agreement with previous studies 11,12,32 showing significantly positive relationships between SHBG and metabolic syndrome. These studies reported that plasma SHBG levels may represent a significant predictor of the metabolic syndrome in men and obese postmenopausal women.…”

Estrogen: A master regulator of bioenergetic systems in the brain and body

“…In humans, there tends to be an inverse relationship between plasma insulin level and SHBG concentration (Akin et al, 2009; Preziosi et al, 1993), which implicates severity of insulin resistance in determining SHBG levels. Insulin resistance and SHBG concentration have been examined in a number of clinical studies, and it has been consistently shown that low SHBG levels correlate with higher HOMA-IR scores (Akin et al, 2007; Akin et al, 2009; Davis et al, 2012b; Kalish et al, 2003; Li et al, 2010; Yasui et al, 2007). This relationship appears independent of BMI (Davis et al, 2012b), but may be mediated by abdominal obesity (Akin et al, 2009).…”

“…Insulin resistance and SHBG concentration have been examined in a number of clinical studies, and it has been consistently shown that low SHBG levels correlate with higher HOMA-IR scores (Akin et al, 2007; Akin et al, 2009; Davis et al, 2012b; Kalish et al, 2003; Li et al, 2010; Yasui et al, 2007). This relationship appears independent of BMI (Davis et al, 2012b), but may be mediated by abdominal obesity (Akin et al, 2009). SHBG is also associated with diabetes risk, and higher plasma levels of SHBG have been linked to lower risk of developing T2DM (Ding et al, 2006; Ding et al, 2009; Kalyani et al, 2009).…”

Hyperglycemia in postmenopausal women screened for the metabolic syndrome is associated to increased sexual complaints

“…Unfortunately, testosterone and/or sexual hormone binding globulin status were not assessed in our series that could give insights on the role of androgen deficit over sexual impairment. However, one must bear in mind that the METS would be a characteristic expression of climacteric hyperandrogenism predominance [4,[51][52][53][54], situation that would contrarily not favor sexual impairment as found in the present series.…”