SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches to <i>Clostridioides difficile</i> prevention

Sandora, Thomas J.; Bryant, Kristina; Cantey, Joseph B.; Elward, Alexis; Yokoe, Deborah S.; Bartlett, Allison H.

doi:10.1017/ice.2018.209

Cited by 9 publications

(3 citation statements)

References 43 publications

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“…This document is part of the "SHEA Neonatal Intensive Care Unit (NICU) White Paper Series." Two documents in the series precede this one: "Practical approaches to Clostridioides difficile prevention" published in August 2018 11 and "Practical approaches to Staphylococcus aureus prevention," published in September 2020. 12 Unlike the SHEA expert guidance format, this document is not based on a systematic literature search.…”

Section: Methodsmentioning

confidence: 99%

SHEA Neonatal Intensive Care Unit (NICU) White Paper Series: Practical approaches for the prevention of central-line–associated bloodstream infections

Muller

Bryant

Espinosa

et al. 2022

Infect. Control Hosp. Epidemiol.

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This document is part of the “SHEA Neonatal Intensive Care Unit (NICU) White Paper Series.” It is intended to provide practical, expert opinion, and/or evidence-based answers to frequently asked questions about CLABSI detection and prevention in the NICU. This document serves as a companion to the CDC Healthcare Infection Control Practices Advisory Committee (HICPAC) Guideline for Prevention of Infections in Neonatal Intensive Care Unit Patients. Central line-associated bloodstream infections (CLABSIs) are among the most frequent invasive infections among infants in the NICU and contribute to substantial morbidity and mortality. Infants who survive CLABSIs have prolonged hospitalization resulting in increased healthcare costs and suffer greater comorbidities including worse neurodevelopmental and growth outcomes. A bundled approach to central line care practices in the NICU has reduced CLABSI rates, but challenges remain. This document was authored by pediatric infectious diseases specialists, neonatologists, advanced practice nurse practitioners, infection preventionists, members of the HICPAC guideline-writing panel, and members of the SHEA Pediatric Leadership Council. For the selected topic areas, the authors provide practical approaches in question-and-answer format, with answers based on consensus expert opinion within the context of the literature search conducted for the companion HICPAC document and supplemented by other published information retrieved by the authors. Two documents in the series precede this one: “Practical approaches to Clostridioides difficile prevention” published in August 2018 and “Practical approaches to Staphylococcus aureus prevention,” published in September 2020.

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Section: Methodsmentioning

confidence: 99%

SHEA Neonatal Intensive Care Unit (NICU) White Paper Series: Practical approaches for the prevention of central-line–associated bloodstream infections

Muller

Bryant

Espinosa

et al. 2022

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

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“…This document is part of a SHEA white paper series that includes the "SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches to Clostridioides difficile prevention," published in August 2018. 11 SHEA convened a group of experts in pediatrics and neonatology, called the NICU Advisory Panel (see the Acknowledgments section), to oversee the full white paper series. The NICU Advisory Panel members serve as representatives for the following organizations: SHEA, the American Hospital Association (AHA), the American Academy of Pediatrics (AAP), the Association for Professionals in Infection Control and Epidemiology (APIC), the Infectious Diseases Society of America (IDSA), The Joint Commission, the National Association of Neonatal Nurses (NANN), the Pediatric Infectious Diseases Society (PIDS), and the Vermont Oxford Network (VON).…”

Section: Methodsmentioning

confidence: 99%

SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches to Staphylococcus aureus disease prevention

Akinboyo¹,

Zangwill²,

Berg³

et al. 2020

Infect. Control Hosp. Epidemiol.

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“…In the absence of evidence challenging this finding, concerns about poor specificity in addition to existing concerns about poor sensitivity have precluded recommendations for use of toxin EIAs in pediatric patients. 7 Our objective was to assess the frequency of false-positive toxin EIA results using two commercial toxin EIAs in children without C. difficile carriage or infection.…”

Section: Introductionmentioning

confidence: 99%

Lack of false-positive results for Clostridioides difficile toxins A and B using two commercial enzyme immunoassays in pediatric patients

Balaji

Kociolek

2019

Infect. Control Hosp. Epidemiol.

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testing where use of highly sensitive toxin gene PCR assays would result in frequent misdiagnosis of CDI in patients with C. difficile carriage. 5 Compared to adult patients, studies of C. difficile test performance in pediatric patients are relatively limited. A previous pediatric study reported high prevalence (36%) of falsepositive toxin EIA results in children. 6 This anomalous finding has not been corroborated in adult or other pediatric populations. In the absence of evidence challenging this finding, concerns about poor specificity in addition to existing concerns about poor sensitivity have precluded recommendations for use of toxin EIAs in pediatric patients. 7 Our objective was to assess the frequency of false-positive toxin EIA results using two commercial toxin EIAs in children without C. difficile carriage or infection. Methods The clinical microbiology laboratory at Lurie Children's Hospital performs C. difficile testing on unformed stools from children at least 12 months old. De-identified clinical stool specimens that tested negative by tcdB PCR (Xpert C. difficile, Cepheid, Sunnyvale, CA) were aliquoted and stored at −80 o C for further testing. After a single freeze-thaw cycle, stools underwent two different C. difficile lateral flow EIAs: Quik Chek Complete (QCC; Techlab, Blacksburg, VA), which detects both glutamate dehydrogenase (GDH) and toxins A

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SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches to Clostridioides difficile prevention

Cited by 9 publications

References 43 publications

SHEA Neonatal Intensive Care Unit (NICU) White Paper Series: Practical approaches for the prevention of central-line–associated bloodstream infections

SHEA Neonatal Intensive Care Unit (NICU) White Paper Series: Practical approaches for the prevention of central-line–associated bloodstream infections

SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches to Staphylococcus aureus disease prevention

Lack of false-positive results for Clostridioides difficile toxins A and B using two commercial enzyme immunoassays in pediatric patients

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