Using carbon fiber-reinforced composite (CFRP) grid stirrups to replace traditional steel stirrups in reinforced concrete (RC) beams can effectively improve the corrosion resistance of structures in marine environments. In this study, the durability of RC beams with CFRP grid stirrups under the coupled effects of sustained loads and immersion in seawater was studied. The sustained loads were set at 24% and 48% of the ultimate bearing capacity of the RC beam, and the specimens were immersed in artificial seawater at room temperature for 90 days, 180 days, and 360 days, respectively. The crack load and shear capacity of the beam were measured at the scheduled time. The initial stiffness of the beam decreased as the immersion time increased, and the higher the sustained load was, the lower the initial stiffness of the conditioned beam. The contribution of the CFRP grid stirrup to the shear load capacity after the cracking load was reached was more significant than that before. The effects of the 48% sustained load on the ultimate tensile strain of the CFRP stirrup were more significant than those for the 24% sustained load. Both immersion and sustained loading improved the cracking load and shear capacity of the beam, and the contribution of sustained loading to the shear capacity decreased as the immersion time and the sustained load level increased. Equations were proposed for predicting the shear strength of RC beams with CFRP grid stirrups under sustained loading and seawater immersion.