High-strength steel (HSS) is widely used in engineering structures, with its superior material performance. Corrosion issue tends to occur in steel structures with time. Corrosion effects on mechanical performance of Q620 HSS were investigated experimentally. The electrochemical accelerated corrosion test was conducted to get corroded Q620 HSS specimens (ρ = 0 ~ 60%). With increases in corrosion degree, corrosion performance became more and more non-uniform. The tensile coupon test was conducted to clarify mechanical properties of corroded Q620 HSS specimens. With increases in corrosion degree, fy, fu, εu and E decreased, correspondingly. The effect of corrosion on εy could be ignored. With the deepening of corrosion, the necking of Q620 HSS specimens was weakened, which reduced the ductility. Based on the numerical fitting, the relationship between corrosion degree and mechanical properties was clarified.