Masonry structures are notoriously vulnerable to horizontal actions caused by earthquakes. Given the high seismicity of the European region, and that the European building stock comprises a lot of masonry buildings, knowledge about their structural response to seismic excitation is particularly important, but at the same time difficult to determine, due to the heterogenous nature of materials and/or constructional techniques in use. An additional issue is represented by the current methods for mechanical properties assessment, that do not provide a reliable framework for accurate structural estimations of existing buildings characterized by different typological properties. Every structure, in other words, should be separately inspected in regard to its mechanical behaviour, based on dedicated approaches able to capture potential critical issues. In this review paper, an insight on the Croatian ARES project is presented (Assessment and Rehabilitation of Existing Structures), including a state-of-the-art of the actual building stock and giving evidence of major difficulties concerning the assessment of existing structures. The most commonly used techniques and tools are compared, with a focus on their basic features and field of application. A brief overview of prevailing structural behaviours and Finite Element numerical modelling issues are also mentioned. As shown, the general tendency is to ensure “sustainable” and energy-efficient building systems. The latter, however, seem in disagreement with basic principles of structural maintenance and renovation. The aim of the ongoing ARES project, in this context, is to improve the current knowledge regarding the assessment and strengthening of structures, with a focus on a more reliable design and maintenance process for existing masonry buildings.