Shear rate analysis of water dynamic in the continuous stirred tank

Tulus, .; Mardiningsih,; Sawaluddin,; Sitompul, Opim Salim; Ihsan, Ahmad Kamal Ariffin Mohd

doi:10.1088/1757-899x/308/1/012048

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…In this context, stirring supplies drag forces that act opposite of the cellulosic material direction of motion. These forces are believed to increase material swelling, and their nature is described amongst others by Tulus et al [29]. The type of applied stirring is not believed to decrease polymer chain lengths to a large extent.…”

Section: Overview Of Experimental Dissolution Of Cellulose By Alkali Solventsmentioning

confidence: 87%

Computational Study of the Dissolution of Cellulose into Single Chains: the Role of the Solvent and Agitation

Bering¹,

Torstensen²,

Lervik³

et al. 2021

Preprint

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We investigate the dissolution mechanism of cellulose using molecular dynamics simulations in both water and a mixture solvent consisting of water with Na + , OH - and urea. As a first computational study of its kind, we apply periodic external forces that mimic agitation of the suspension. Without the agitation, the bundles do not dissolve, neither in water nor solvent. In the solvent mixture the bundle swells up with significant amounts of urea entering the bundle, as well as more water than in the bundles subjected to pure water. We also find that the mixture solution stabilizes cellulose sheets, while in water these immediately collapse into bundles. Under agitation the bundles dissolve more easily in the solvent mixture than in water, where sheets of cellulose remain that are bound together through hydrophobic interactions. Our findings highlight the importance of urea in the solvent, as well as the hydrophobic interactions, and are consistent with experimental results.

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Section: Overview Of Experimental Dissolution Of Cellulose By Alkali Solventsmentioning

confidence: 87%

Computational Study of the Dissolution of Cellulose into Single Chains: the Role of the Solvent and Agitation

Bering¹,

Torstensen²,

Lervik³

et al. 2021

Preprint

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“…The manufacturing method is robust and can tolerate high pressures up to 250 psi or more without any trace of channel disruption or crack propagation [43]. The shear stress applied by this micromixer was as small as 1 Pa for Re lower than 100, which is very small compared to the shear stress generated by the stirring tank used in the stem cell industry (which can go up to 300 Pa) [40,44,45]. This shear stress is also smaller than other microfluidic devices which are considered to be harmless to the cells [46].…”

Section: Discussionmentioning

confidence: 99%

Rapid and Continuous Cryopreservation of Stem Cells with a 3D Micromixer

et al. 2022

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Cryopreservation is the final step of stem cell production before the cryostorage of the product. Conventional methods of adding cryoprotecting agents (CPA) into the cells can be manual or automated with robotic arms. However, challenging issues with these methods at industrial-scale production are the insufficient mixing of cells and CPA, leading to damage of cells, discontinuous feeding, the batch-to-batch difference in products, and, occasionally, cross-contamination. Therefore, the current study proposes an alternative way to overcome the abovementioned challenges; a highly efficient micromixer for low-cost, continuous, labour-free, and automated mixing of stem cells with CPA solutions. Our results show that our micromixer provides a more homogenous mixing of cells and CPA compared to the manual mixing method, while the cell properties, including surface markers, differentiation potential, proliferation, morphology, and therapeutic potential, are well preserved.

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“…To determine the effect of shear on CT, temperature ramps for 50MeM:50MeS were performed at two different shear rates of 10 and 100 s À1 , which are common shear rates in industrial processes. For example, average shear rate in continuous stirred tank ranges $100 s À1 (Tulus et al, 2018). Cooling rate effect on CT was probed using temperature ramps with constant cooling rate of 0.1 and 1 C/min and shear rate of 100 s À1 .…”

Section: Methodsmentioning

confidence: 99%

Flow and crystallization of saturated fatty acid methyl esters and their binary mixtures

Helsper

Hatem

Young

et al. 2022

J Americ Oil Chem Soc

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Demand for biodiesel has increased due to being a more environmentally‐friendly fuel. Cold weather operation of biodiesel is challenging due to fatty acid methyl ester (FAME) content in biodiesel. Saturated FAMEs crystallize at relatively high temperatures, increase the viscosity of biodiesel, and can clog fuel lines. Here, several factors altered crystallization temperature (CT) of FAMEs, including composition, shear rate, and cooling rate. The crystallization of pure and binary mixtures of methyl palmitate, methyl myristate, and methyl stearate were studied under shear flow and static conditions. Static phase CTs of pure methyl palmitate, methyl myristate, and methyl stearate were 26, 14, and 35°C, respectively. In binary mixtures, CTs were depressed up to 7°C, which agreed with freezing point depression theory. Increasing shear rate up to 100 s−1 decreased CT by 2°C compared to static conditions. Decreasing cooling rate from 1 to 0.1°C/min increased CT less than 2°C. Overall, FAME composition altered CT more than shear flow or cooling rate for pure and binary mixtures of three FAMEs.

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Shear rate analysis of water dynamic in the continuous stirred tank

Cited by 6 publications

References 2 publications

Computational Study of the Dissolution of Cellulose into Single Chains: the Role of the Solvent and Agitation

Computational Study of the Dissolution of Cellulose into Single Chains: the Role of the Solvent and Agitation

Rapid and Continuous Cryopreservation of Stem Cells with a 3D Micromixer

Flow and crystallization of saturated fatty acid methyl esters and their binary mixtures

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