Shear Wave Elastography Characterizes Passive and Active Mechanical Properties of Biceps Brachii Muscle in Vivo

Zimmer, Manuela; Kleiser, Benedict; Marquetand, Justus; Ateş, Filiz

doi:10.2139/ssrn.4101072

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…In the case of liver cirrhosis, the stiffness corresponds to the progression of the fibrotic remodeling and the disease course (e.g., the higher a liver's SWE measurement, the more advanced the stage of cirrhosis). Recent research is also focusing on functional changes as in the case of increased muscle tone in skeletal muscle tissue [5][6][7]; here, the diagnostic yield of SWE is still under investigation.…”

Section: Figure 1 Visual Description Of Muscle Shear Wave Elastograph...mentioning

confidence: 99%

Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography

et al. 2023

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Rigidity in Parkinson’s disease (PD) is assessed by clinical scales, mostly the Unified Parkinson’s Disease Rating Scale of the Movement Disorders Society (MDS-UPDRS). While the MDS-UPDRS-III ranges on an integer from 0 to 4, we investigated whether muscle ultrasound shear wave elastography (SWE) offers a refined assessment. Ten PD patients (five treated with deep brain stimulation (DBS) and levodopa, five with levodopa only) and ten healthy controls were included. Over a period of 80 min, both the SWE value and the item 22b-c of the MDS-UPDRS-III were measured at 5 min intervals. The measurements were performed bilaterally at the biceps brachii muscle (BB) and flexor digitorum profundus muscle in flexion and passive extension. Rigidity was modified and tracked under various therapeutic conditions (with and without medication/DBS). The feasibility of SWE for objective quantification was evaluated by correlation with the UPDRS-III: considering all positions and muscles, there was already a weak correlation (r = 0.01, p < 0.001)—in a targeted analysis, the BB in passive extension showed a markedly higher correlation (r = 0.494, p < 0.001). The application of dopaminergic medication and DBS resulted in statistically significant short-term changes in both clinical rigidity and SWE measurements in the BB (p < 0.001). We conclude that rigidity is reflected in the SWE measurements, indicating that SWE is a potential non-invasive quantitative assessment tool for PD.

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Section: Figure 1 Visual Description Of Muscle Shear Wave Elastograph...mentioning

confidence: 99%

Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography

et al. 2023

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“…US SWE has been successfully used on skeletal muscle to estimate active and passive mechanical tension ( Hug et al, 2015 ; Zimmer et al, 2022 ), to detect disease ( Alfuraih et al, 2019 ; Boulard et al, 2021 ; Tisha et al, 2018 ) or exercise-induced damage ( Siracusa et al, 2019 ; Lacourpaille et al, 2017 ; Chalchat et al, 2020 ; Lacourpaille et al, 2014 ) and other stimuli ( Sions et al, 2012 ). The most commonly used US SWE systems work with one-dimensional piezo array transducers, which consequently yield quasi-two-dimensional (2D) measurements of tissue stiffness.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional mapping of ultrasound-derived skeletal muscle shear wave velocity

Götschi,

Snedeker,

Fitze

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: The mechanical properties of skeletal muscle are indicative of its capacity to perform physical work, state of disease, or risk of injury. Ultrasound shear wave elastography conducts a quantitative analysis of a tissue’s shear stiffness, but current implementations only provide two-dimensional measurements with limited spatial extent. We propose and assess a framework to overcome this inherent limitation by acquiring numerous and contiguous measurements while tracking the probe position to create a volumetric scan of the muscle. This volume reconstruction is then mapped into a parameterized representation in reference to geometric and anatomical properties of the muscle. Such an approach allows to quantify regional differences in muscle stiffness to be identified across the entire muscle volume assessed, which could be linked to functional implications.Methods: We performed shear wave elastography measurements on the vastus lateralis (VL) and the biceps femoris long head (BFlh) muscle of 16 healthy volunteers. We assessed test-retest reliability, explored the potential of the proposed framework in aggregating measurements of multiple subjects, and studied the acute effects of muscular contraction on the regional shear wave velocity post-measured at rest.Results: The proposed approach yielded moderate to good reliability (ICC between 0.578 and 0.801). Aggregation of multiple subject measurements revealed considerable but consistent regional variations in shear wave velocity. As a result of muscle contraction, the shear wave velocity was elevated in various regions of the muscle; showing pre-to-post regional differences for the radial assessement of VL and longitudinally for BFlh. Post-contraction shear wave velocity was associated with maximum eccentric hamstring strength produced during six Nordic hamstring exercise repetitions.Discussion and Conclusion: The presented approach provides reliable, spatially resolved representations of skeletal muscle shear wave velocity and is capable of detecting changes in three-dimensional shear wave velocity patterns, such as those induced by muscle contraction. The observed systematic inter-subject variations in shear wave velocity throughout skeletal muscle additionally underline the necessity of accurate spatial referencing of measurements. Short high-effort exercise bouts increase muscle shear wave velocity. Further studies should investigate the potential of shear wave elastography in predicting the muscle’s capacity to perform work.

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Towards in vivo non-invasive muscle characterization: Shear wave elastography to assess passive and active mechanics of triceps surae

2023

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Shear Wave Elastography Characterizes Passive and Active Mechanical Properties of Biceps Brachii Muscle in Vivo

Cited by 3 publications

References 34 publications

Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography

Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography

Three-dimensional mapping of ultrasound-derived skeletal muscle shear wave velocity

Towards in vivo non-invasive muscle characterization: Shear wave elastography to assess passive and active mechanics of triceps surae

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